Houk KN - Search Results

1

Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.

Zhang B, Wang KB, Wang W, Wang X, Liu F, Zhu J, Shi J, Li LY, Han H, Xu K, Qiao HY, Zhang X, Jiao RH, Houk KN, Liang Y, Tan RX, Ge HM. Zhang B, et al. Among authors: houk kn. Nature. 2019 Apr;568(7750):122-126. doi: 10.1038/s41586-019-1021-x. Epub 2019 Mar 13. Nature. 2019. PMID: 30867595 Free PMC article.

2

Kemp elimination catalysts by computational enzyme design.

Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D. Röthlisberger D, et al. Among authors: houk kn. Nature. 2008 May 8;453(7192):190-5. doi: 10.1038/nature06879. Epub 2008 Mar 19. Nature. 2008. PMID: 18354394

3

Effect of Lewis acid catalysts on Diels-Alder and hetero-Diels-Alder cycloadditions sharing a common transition state.

Celebi-Olçüm N, Ess DH, Aviyente V, Houk KN. Celebi-Olçüm N, et al. Among authors: houk kn. J Org Chem. 2008 Oct 3;73(19):7472-80. doi: 10.1021/jo801076t. Epub 2008 Sep 10. J Org Chem. 2008. PMID: 18781801

4

Computational prediction of small-molecule catalysts.

Houk KN, Cheong PH. Houk KN, et al. Nature. 2008 Sep 18;455(7211):309-13. doi: 10.1038/nature07368. Nature. 2008. PMID: 18800129 Free PMC article.

5

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.

Hotta K, Chen X, Paton RS, Minami A, Li H, Swaminathan K, Mathews II, Watanabe K, Oikawa H, Houk KN, Kim CY. Hotta K, et al. Among authors: houk kn. Nature. 2012 Mar 4;483(7389):355-8. doi: 10.1038/nature10865. Nature. 2012. PMID: 22388816 Free PMC article.

6

Engineering synthetic recursive pathways to generate non-natural small molecules.

Felnagle EA, Chaubey A, Noey EL, Houk KN, Liao JC. Felnagle EA, et al. Among authors: houk kn. Nat Chem Biol. 2012 May 17;8(6):518-26. doi: 10.1038/nchembio.959. Nat Chem Biol. 2012. PMID: 22596203 Review.

7

Control and design of mutual orthogonality in bioorthogonal cycloadditions.

Liang Y, Mackey JL, Lopez SA, Liu F, Houk KN. Liang Y, et al. Among authors: houk kn. J Am Chem Soc. 2012 Oct 31;134(43):17904-7. doi: 10.1021/ja309241e. Epub 2012 Oct 17. J Am Chem Soc. 2012. PMID: 23061442

8

Reversible photochemically gated transformation of a hemicarcerand to a carcerand.

Wang H, Liu F, Helgeson RC, Houk KN. Wang H, et al. Among authors: houk kn. Angew Chem Int Ed Engl. 2013 Jan 7;52(2):655-9. doi: 10.1002/anie.201205376. Epub 2012 Nov 22. Angew Chem Int Ed Engl. 2013. PMID: 23172821

9

Metal-free oxidation of aromatic carbon-hydrogen bonds through a reverse-rebound mechanism.

Yuan C, Liang Y, Hernandez T, Berriochoa A, Houk KN, Siegel D. Yuan C, et al. Among authors: houk kn. Nature. 2013 Jul 11;499(7457):192-6. doi: 10.1038/nature12284. Nature. 2013. PMID: 23846658

10

Isomeric cyclopropenes exhibit unique bioorthogonal reactivities.

Kamber DN, Nazarova LA, Liang Y, Lopez SA, Patterson DM, Shih HW, Houk KN, Prescher JA. Kamber DN, et al. Among authors: houk kn. J Am Chem Soc. 2013 Sep 18;135(37):13680-3. doi: 10.1021/ja407737d. Epub 2013 Sep 6. J Am Chem Soc. 2013. PMID: 24000889

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