Ernst M - Search Results

1

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Thilakasiri P, Huynh J, Poh AR, Tan CW, Nero TL, Tran K, Parslow AC, Afshar-Sterle S, Baloyan D, Hannan NJ, Buchert M, Scott AM, Griffin MD, Hollande F, Parker MW, Putoczki TL, Ernst M, Chand AL. Thilakasiri P, et al. Among authors: ernst m. EMBO Mol Med. 2019 Apr;11(4):e9539. doi: 10.15252/emmm.201809539. EMBO Mol Med. 2019. PMID: 30885958 Free PMC article.

2

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.

Ernst M, Inglese M, Waring P, Campbell IK, Bao S, Clay FJ, Alexander WS, Wicks IP, Tarlinton DM, Novak U, Heath JK, Dunn AR. Ernst M, et al. J Exp Med. 2001 Jul 16;194(2):189-203. doi: 10.1084/jem.194.2.189. J Exp Med. 2001. PMID: 11457894 Free PMC article.

3

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.

Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ, Malki S, Alderman BM, Grail D, Hollande F, Heath JK, Ernst M. Tebbutt NC, et al. Among authors: ernst m. Nat Med. 2002 Oct;8(10):1089-97. doi: 10.1038/nm763. Epub 2002 Sep 9. Nat Med. 2002. PMID: 12219085

4

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu HJ, Ernst M. Jenkins BJ, et al. Among authors: ernst m. Nat Med. 2005 Aug;11(8):845-52. doi: 10.1038/nm1282. Epub 2005 Jul 24. Nat Med. 2005. PMID: 16041381

5

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

Ernst M, Najdovska M, Grail D, Lundgren-May T, Buchert M, Tye H, Matthews VB, Armes J, Bhathal PS, Hughes NR, Marcusson EG, Karras JG, Na S, Sedgwick JD, Hertzog PJ, Jenkins BJ. Ernst M, et al. J Clin Invest. 2008 May;118(5):1727-38. doi: 10.1172/JCI34944. J Clin Invest. 2008. PMID: 18431520 Free PMC article.

6

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR. Bollrath J, et al. Among authors: ernst m. Cancer Cell. 2009 Feb 3;15(2):91-102. doi: 10.1016/j.ccr.2009.01.002. Cancer Cell. 2009. PMID: 19185844 Free article.

7

Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling.

Samuel MS, Suzuki H, Buchert M, Putoczki TL, Tebbutt NC, Lundgren-May T, Christou A, Inglese M, Toyota M, Heath JK, Ward RL, Waring PM, Ernst M. Samuel MS, et al. Among authors: ernst m. Gastroenterology. 2009 Sep;137(3):902-13, 913.e1-11. doi: 10.1053/j.gastro.2009.05.042. Epub 2009 May 18. Gastroenterology. 2009. PMID: 19454286

8

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M. Buchert M, et al. Among authors: ernst m. PLoS Genet. 2010 Jan 15;6(1):e1000816. doi: 10.1371/journal.pgen.1000816. PLoS Genet. 2010. PMID: 20084116 Free PMC article.

9

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

Jarnicki A, Putoczki T, Ernst M. Jarnicki A, et al. Among authors: ernst m. Cell Div. 2010 May 17;5:14. doi: 10.1186/1747-1028-5-14. Cell Div. 2010. PMID: 20478049 Free PMC article.

10

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer.

Putoczki T, Ernst M. Putoczki T, et al. Among authors: ernst m. J Leukoc Biol. 2010 Dec;88(6):1109-17. doi: 10.1189/jlb.0410226. Epub 2010 Jul 7. J Leukoc Biol. 2010. PMID: 20610798 Review.

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