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Page 1
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.
Fukuzawa T, Sampei Z, Haraya K, Ruike Y, Shida-Kawazoe M, Shimizu Y, Gan SW, Irie M, Tsuboi Y, Tai H, Sakiyama T, Sakamoto A, Ishii S, Maeda A, Iwayanagi Y, Shibahara N, Shibuya M, Nakamura G, Nambu T, Hayasaka A, Mimoto F, Okura Y, Hori Y, Habu K, Wada M, Miura T, Tachibana T, Honda K, Tsunoda H, Kitazawa T, Kawabe Y, Igawa T, Hattori K, Nezu J. Fukuzawa T, et al. Sci Rep. 2017 Apr 24;7(1):1080. doi: 10.1038/s41598-017-01087-7. Sci Rep. 2017. PMID: 28439081 Free PMC article.
An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors.
Ishiguro T, Sano Y, Komatsu SI, Kamata-Sakurai M, Kaneko A, Kinoshita Y, Shiraiwa H, Azuma Y, Tsunenari T, Kayukawa Y, Sonobe Y, Ono N, Sakata K, Fujii T, Miyazaki Y, Noguchi M, Endo M, Harada A, Frings W, Fujii E, Nanba E, Narita A, Sakamoto A, Wakabayashi T, Konishi H, Segawa H, Igawa T, Tsushima T, Mutoh H, Nishito Y, Takahashi M, Stewart L, ElGabry E, Kawabe Y, Ishigai M, Chiba S, Aoki M, Hattori K, Nezu J. Ishiguro T, et al. Sci Transl Med. 2017 Oct 4;9(410):eaal4291. doi: 10.1126/scitranslmed.aal4291. Sci Transl Med. 2017. PMID: 28978751
Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974.
Shiraiwa H, Narita A, Kamata-Sakurai M, Ishiguro T, Sano Y, Hironiwa N, Tsushima T, Segawa H, Tsunenari T, Ikeda Y, Kayukawa Y, Noguchi M, Wakabayashi T, Sakamoto A, Konishi H, Kuramochi T, Endo M, Hattori K, Nezu J, Igawa T. Shiraiwa H, et al. Methods. 2019 Feb 1;154:10-20. doi: 10.1016/j.ymeth.2018.10.005. Epub 2018 Oct 13. Methods. 2019. PMID: 30326272
Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody.
Sampei Z, Haraya K, Tachibana T, Fukuzawa T, Shida-Kawazoe M, Gan SW, Shimizu Y, Ruike Y, Feng S, Kuramochi T, Muraoka M, Kitazawa T, Kawabe Y, Igawa T, Hattori K, Nezu J. Sampei Z, et al. PLoS One. 2018 Dec 28;13(12):e0209509. doi: 10.1371/journal.pone.0209509. eCollection 2018. PLoS One. 2018. PMID: 30592762 Free PMC article.
Novel myostatin-specific antibody enhances muscle strength in muscle disease models.
Muramatsu H, Kuramochi T, Katada H, Ueyama A, Ruike Y, Ohmine K, Shida-Kawazoe M, Miyano-Nishizawa R, Shimizu Y, Okuda M, Hori Y, Hayashi M, Haraya K, Ban N, Nonaka T, Honda M, Kitamura H, Hattori K, Kitazawa T, Igawa T, Kawabe Y, Nezu J. Muramatsu H, et al. Sci Rep. 2021 Jan 25;11(1):2160. doi: 10.1038/s41598-021-81669-8. Sci Rep. 2021. PMID: 33495503 Free PMC article.
Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics.
Ueda O, Wada NA, Kinoshita Y, Hino H, Kakefuda M, Ito T, Fujii E, Noguchi M, Sato K, Morita M, Tateishi H, Matsumoto K, Goto C, Kawase Y, Kato A, Hattori K, Nezu J, Ishiguro T, Jishage KI. Ueda O, et al. Sci Rep. 2017 Apr 3;7:45839. doi: 10.1038/srep45839. Sci Rep. 2017. PMID: 28368009 Free PMC article.
55 results