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Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity.
Li Y, Evers R, Hafey MJ, Cheon K, Duong H, Lynch D, LaFranco-Scheuch L, Pacchione S, Tamburino AM, Tanis KQ, Geddes K, Holder D, Zhang NR, Kang W, Gonzalez RJ, Galijatovic-Idrizbegovic A, Pearson KM, Lebron JA, Glaab WE, Sistare FD. Li Y, et al. Among authors: tanis kq. Toxicol Sci. 2019 Jul 1;170(1):180-198. doi: 10.1093/toxsci/kfz079. Toxicol Sci. 2019. PMID: 30903168
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline.
Kang W, Podtelezhnikov AA, Tanis KQ, Pacchione S, Su M, Bleicher KB, Wang Z, Laws GM, Griffiths TG, Kuhls MC, Chen Q, Knemeyer I, Marsh DJ, Mitra K, Lebron J, Sistare FD. Kang W, et al. Among authors: tanis kq. Toxicol Sci. 2020 Sep 1;177(1):121-139. doi: 10.1093/toxsci/kfaa094. Toxicol Sci. 2020. PMID: 32559289
Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.
Monroe JJ, Tanis KQ, Podtelezhnikov AA, Nguyen T, Machotka SV, Lynch D, Evers R, Palamanda J, Miller RR, Pippert T, Cabalu TD, Johnson TE, Aslamkhan AG, Kang W, Tamburino AM, Mitra K, Agrawal NGB, Sistare FD. Monroe JJ, et al. Among authors: tanis kq. Toxicol Sci. 2020 Sep 1;177(1):281-299. doi: 10.1093/toxsci/kfaa088. Toxicol Sci. 2020. PMID: 32559301 Free PMC article.
Toxicogenomics in drug development: a match made in heaven?
Qin C, Tanis KQ, Podtelezhnikov AA, Glaab WE, Sistare FD, DeGeorge JJ. Qin C, et al. Among authors: tanis kq. Expert Opin Drug Metab Toxicol. 2016 Aug;12(8):847-9. doi: 10.1080/17425255.2016.1175437. Epub 2016 Apr 21. Expert Opin Drug Metab Toxicol. 2016. PMID: 27050123 No abstract available.
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.
Corton JC, Mitchell CA, Auerbach S, Bushel P, Ellinger-Ziegelbauer H, Escobar PA, Froetschl R, Harrill AH, Johnson K, Klaunig JE, Pandiri AR, Podtelezhnikov AA, Rager JE, Tanis KQ, van der Laan JW, Vespa A, Yauk CL, Pettit SD, Sistare FD. Corton JC, et al. Among authors: tanis kq. Toxicol Sci. 2022 Jun 28;188(1):4-16. doi: 10.1093/toxsci/kfac041. Toxicol Sci. 2022. PMID: 35404422 Free PMC article.
29 results