McLaren AW - Search Results

1

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

Henderson CJ, Kapelyukh Y, Scheer N, Rode A, McLaren AW, MacLeod AK, Lin D, Wright J, Stanley LA, Wolf CR. Henderson CJ, et al. Among authors: mclaren aw. Drug Metab Dispos. 2019 Jun;47(6):601-615. doi: 10.1124/dmd.119.086397. Epub 2019 Mar 25. Drug Metab Dispos. 2019. PMID: 30910785 Free PMC article.

2

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

Forrester LM, Henderson CJ, Glancey MJ, Back DJ, Park BK, Ball SE, Kitteringham NR, McLaren AW, Miles JS, Skett P, et al. Forrester LM, et al. Among authors: mclaren aw. Biochem J. 1992 Jan 15;281 ( Pt 2)(Pt 2):359-68. doi: 10.1042/bj2810359. Biochem J. 1992. PMID: 1736885 Free PMC article.

3

Alternative splicing in the human cytochrome P450IIB6 gene: use of a cryptic exon within intron 3 and splice acceptor site within exon 4.

Miles JS, McLaren AW, Gonzalez FJ, Wolf CR. Miles JS, et al. Among authors: mclaren aw. Nucleic Acids Res. 1990 Jan 11;18(1):189. doi: 10.1093/nar/18.1.189. Nucleic Acids Res. 1990. PMID: 2308828 Free PMC article. No abstract available.

4

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.

Miles JS, McLaren AW, Forrester LM, Glancey MJ, Lang MA, Wolf CR. Miles JS, et al. Among authors: mclaren aw. Biochem J. 1990 Apr 15;267(2):365-71. doi: 10.1042/bj2670365. Biochem J. 1990. PMID: 2334398 Free PMC article.

5

Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.

Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R, Wolf CR. Miles JS, et al. Among authors: mclaren aw. Nucleic Acids Res. 1989 Apr 25;17(8):2907-17. doi: 10.1093/nar/17.8.2907. Nucleic Acids Res. 1989. PMID: 2726448 Free PMC article.

6

Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.

Miles JS, McLaren AW, Wolf CR. Miles JS, et al. Among authors: mclaren aw. Nucleic Acids Res. 1989 Oct 25;17(20):8241-55. doi: 10.1093/nar/17.20.8241. Nucleic Acids Res. 1989. PMID: 2813061 Free PMC article.

7

A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing.

Miles JS, Spurr NK, Gough AC, Jowett T, McLaren AW, Brook JD, Wolf CR. Miles JS, et al. Among authors: mclaren aw. Nucleic Acids Res. 1988 Jul 11;16(13):5783-95. doi: 10.1093/nar/16.13.5783. Nucleic Acids Res. 1988. PMID: 2899870 Free PMC article.

8

Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells.

Moffat GJ, McLaren AW, Wolf CR. Moffat GJ, et al. Among authors: mclaren aw. J Biol Chem. 1994 Jun 10;269(23):16397-402. J Biol Chem. 1994. PMID: 8206948 Free article.

9

Sp1-mediated transcriptional activation of the human Pi class glutathione S-transferase promoter.

Moffat GJ, McLaren AW, Wolf CR. Moffat GJ, et al. Among authors: mclaren aw. J Biol Chem. 1996 Jan 12;271(2):1054-60. doi: 10.1074/jbc.271.2.1054. J Biol Chem. 1996. PMID: 8557630 Free article.

10

Functional characterization of the transcription silencer element located within the human Pi class glutathione S-transferase promoter.

Moffat GJ, McLaren AW, Wolf CR. Moffat GJ, et al. Among authors: mclaren aw. J Biol Chem. 1996 Aug 23;271(34):20740-7. doi: 10.1074/jbc.271.34.20740. J Biol Chem. 1996. PMID: 8702826 Free article.

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