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Insights into the Mechanism of the Cyanobactin Heterocyclase Enzyme.
Ge Y, Czekster CM, Miller OK, Botting CH, Schwarz-Linek U, Naismith JH. Ge Y, et al. Among authors: botting ch. Biochemistry. 2019 Apr 23;58(16):2125-2132. doi: 10.1021/acs.biochem.9b00084. Epub 2019 Apr 5. Biochemistry. 2019. PMID: 30912640 Free PMC article.
The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction.
Koehnke J, Bent AF, Zollman D, Smith K, Houssen WE, Zhu X, Mann G, Lebl T, Scharff R, Shirran S, Botting CH, Jaspars M, Schwarz-Linek U, Naismith JH. Koehnke J, et al. Among authors: botting ch. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):13991-6. doi: 10.1002/anie.201306302. Epub 2013 Nov 8. Angew Chem Int Ed Engl. 2013. PMID: 24214017 Free PMC article. No abstract available.
An enzymatic route to selenazolines.
Koehnke J, Morawitz F, Bent AF, Houssen WE, Shirran SL, Fuszard MA, Smellie IA, Botting CH, Smith MC, Jaspars M, Naismith JH. Koehnke J, et al. Among authors: botting ch. Chembiochem. 2013 Mar 18;14(5):564-7. doi: 10.1002/cbic.201300037. Epub 2013 Feb 18. Chembiochem. 2013. PMID: 23483642 Free PMC article.
The Scottish Structural Proteomics Facility: targets, methods and outputs.
Oke M, Carter LG, Johnson KA, Liu H, McMahon SA, Yan X, Kerou M, Weikart ND, Kadi N, Sheikh MA, Schmelz S, Dorward M, Zawadzki M, Cozens C, Falconer H, Powers H, Overton IM, van Niekerk CA, Peng X, Patel P, Garrett RA, Prangishvili D, Botting CH, Coote PJ, Dryden DT, Barton GJ, Schwarz-Linek U, Challis GL, Taylor GL, White MF, Naismith JH. Oke M, et al. Among authors: botting ch. J Struct Funct Genomics. 2010 Jun;11(2):167-80. doi: 10.1007/s10969-010-9090-y. Epub 2010 Apr 24. J Struct Funct Genomics. 2010. PMID: 20419351 Free PMC article.
An internal thioester in a pathogen surface protein mediates covalent host binding.
Walden M, Edwards JM, Dziewulska AM, Bergmann R, Saalbach G, Kan SY, Miller OK, Weckener M, Jackson RJ, Shirran SL, Botting CH, Florence GJ, Rohde M, Banfield MJ, Schwarz-Linek U. Walden M, et al. Among authors: botting ch. Elife. 2015 Jun 2;4:e06638. doi: 10.7554/eLife.06638. Elife. 2015. PMID: 26032562 Free PMC article.
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis.
Schmelz S, Kadi N, McMahon SA, Song L, Oves-Costales D, Oke M, Liu H, Johnson KA, Carter LG, Botting CH, White MF, Challis GL, Naismith JH. Schmelz S, et al. Among authors: botting ch. Nat Chem Biol. 2009 Mar;5(3):174-82. doi: 10.1038/nchembio.145. Epub 2009 Feb 1. Nat Chem Biol. 2009. PMID: 19182782 Free PMC article.
96 results