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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart A, Anderson K, Mainolfi N, Sellner H, Ehara T, Adams CM, Mac Sweeney A, Liao SM, Crowley M, Littlewood-Evans A, Sarret S, Wieczorek G, Perrot L, Dubost V, Flandre T, Zhang Y, Smith RJH, Risitano AM, Karki RG, Zhang C, Valeur E, Sirockin F, Gerhartz B, Erbel P, Hughes N, Smith TM, Cumin F, Argikar UA, Haraldsson B, Mogi M, Sedrani R, Wiesmann C, Jaffee B, Maibaum J, Flohr S, Harrison R, Eder J. Schubart A, et al. Among authors: smith rjh, smith tm. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931. doi: 10.1073/pnas.1820892116. Epub 2019 Mar 29. Proc Natl Acad Sci U S A. 2019. PMID: 30926668 Free PMC article.
Causes of alternative pathway dysregulation in dense deposit disease.
Zhang Y, Meyer NC, Wang K, Nishimura C, Frees K, Jones M, Katz LM, Sethi S, Smith RJ. Zhang Y, et al. Clin J Am Soc Nephrol. 2012 Feb;7(2):265-74. doi: 10.2215/CJN.07900811. Epub 2012 Jan 5. Clin J Am Soc Nephrol. 2012. PMID: 22223606 Free PMC article.
CFTR-deficient pigs display peripheral nervous system defects at birth.
Reznikov LR, Dong Q, Chen JH, Moninger TO, Park JM, Zhang Y, Du J, Hildebrand MS, Smith RJ, Randak CO, Stoltz DA, Welsh MJ. Reznikov LR, et al. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3083-8. doi: 10.1073/pnas.1222729110. Epub 2013 Feb 4. Proc Natl Acad Sci U S A. 2013. PMID: 23382208 Free PMC article.
Soluble CR1 therapy improves complement regulation in C3 glomerulopathy.
Zhang Y, Nester CM, Holanda DG, Marsh HC, Hammond RA, Thomas LJ, Meyer NC, Hunsicker LG, Sethi S, Smith RJ. Zhang Y, et al. J Am Soc Nephrol. 2013 Nov;24(11):1820-9. doi: 10.1681/ASN.2013010045. Epub 2013 Aug 1. J Am Soc Nephrol. 2013. PMID: 23907509 Free PMC article.
Defining the complement biomarker profile of C3 glomerulopathy.
Zhang Y, Nester CM, Martin B, Skjoedt MO, Meyer NC, Shao D, Borsa N, Palarasah Y, Smith RJ. Zhang Y, et al. Clin J Am Soc Nephrol. 2014 Nov 7;9(11):1876-82. doi: 10.2215/CJN.01820214. Epub 2014 Oct 23. Clin J Am Soc Nephrol. 2014. PMID: 25341722 Free PMC article.
388 results