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Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
Heightman TD, Callahan JF, Chiarparin E, Coyle JE, Griffiths-Jones C, Lakdawala AS, McMenamin R, Mortenson PN, Norton D, Peakman TM, Rich SJ, Richardson C, Rumsey WL, Sanchez Y, Saxty G, Willems HMG, Wolfe L 3rd, Woolford AJ, Wu Z, Yan H, Kerns JK, Davies TG. Heightman TD, et al. Among authors: callahan jf. J Med Chem. 2019 May 9;62(9):4683-4702. doi: 10.1021/acs.jmedchem.9b00279. Epub 2019 Apr 25. J Med Chem. 2019. PMID: 30973731
Structure-activity relationships of novel hematoregulatory peptides.
Bhatnagar PK, Agner EK, Alberts D, Arbo BE, Callahan JF, Cuthbertson AS, Engelsen SJ, Fjerdingstad H, Hartmann M, Heerding D, Hiebl J, Huffman WF, Hysben M, King AG, Kremminger P, Kwon C, LoCastro S, Løvhaug D, Pelus LM, Petteway S, Takata JS. Bhatnagar PK, et al. Among authors: callahan jf. J Med Chem. 1996 Sep 13;39(19):3814-9. doi: 10.1021/jm960099d. J Med Chem. 1996. PMID: 8809169
Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
Keenan RM, Miller WH, Kwon C, Ali FE, Callahan JF, Calvo RR, Hwang SM, Kopple KD, Peishoff CE, Samanen JM, Wong AS, Yuan CK, Huffman WF. Keenan RM, et al. Among authors: callahan jf. J Med Chem. 1997 Jul 18;40(15):2289-92. doi: 10.1021/jm970205r. J Med Chem. 1997. PMID: 9240343 No abstract available.
Conformational preferences in a benzodiazepine series of potent nonpeptide fibrinogen receptor antagonists.
Keenan RM, Callahan JF, Samanen JM, Bondinell WE, Calvo RR, Chen L, DeBrosse C, Eggleston DS, Haltiwanger RC, Hwang SM, Jakas DR, Ku TW, Miller WH, Newlander KA, Nichols A, Parker MF, Southhall LS, Uzinskas I, Vasko-Moser JA, Venslavsky JW, Wong AS, Huffman WF. Keenan RM, et al. Among authors: callahan jf. J Med Chem. 1999 Feb 25;42(4):545-59. doi: 10.1021/jm980166z. J Med Chem. 1999. PMID: 10052962
Progress towards the development of anti-inflammatory inhibitors of IKKbeta.
Bamborough P, Callahan JF, Christopher JA, Kerns JK, Liddle J, Miller DD, Morse MA, Rumsey WL, Williamson R. Bamborough P, et al. Among authors: callahan jf. Curr Top Med Chem. 2009;9(7):623-39. doi: 10.2174/156802609789007336. Curr Top Med Chem. 2009. PMID: 19689370 Review.
Keap calm, and carry on covalently.
Wilson AJ, Kerns JK, Callahan JF, Moody CJ. Wilson AJ, et al. Among authors: callahan jf. J Med Chem. 2013 Oct 10;56(19):7463-76. doi: 10.1021/jm400224q. Epub 2013 Jul 25. J Med Chem. 2013. PMID: 23837912
52 results