Gregory KJ - Search Results

1

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5.

Chen ANY, Hellyer SD, Trinh PNH, Leach K, Gregory KJ. Chen ANY, et al. Among authors: gregory kj. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6:104-115. doi: 10.1111/bcpt.13239. Epub 2019 May 7. Basic Clin Pharmacol Toxicol. 2020. PMID: 30983151 Free article.

2

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.

Avlani VA, Gregory KJ, Morton CJ, Parker MW, Sexton PM, Christopoulos A. Avlani VA, et al. Among authors: gregory kj. J Biol Chem. 2007 Aug 31;282(35):25677-86. doi: 10.1074/jbc.M702311200. Epub 2007 Jun 25. J Biol Chem. 2007. PMID: 17591774 Free article.

3

A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

Valant C, Gregory KJ, Hall NE, Scammells PJ, Lew MJ, Sexton PM, Christopoulos A. Valant C, et al. Among authors: gregory kj. J Biol Chem. 2008 Oct 24;283(43):29312-21. doi: 10.1074/jbc.M803801200. Epub 2008 Aug 22. J Biol Chem. 2008. PMID: 18723515 Free PMC article.

4

Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias.

Gregory KJ, Hall NE, Tobin AB, Sexton PM, Christopoulos A. Gregory KJ, et al. J Biol Chem. 2010 Mar 5;285(10):7459-74. doi: 10.1074/jbc.M109.094011. Epub 2010 Jan 5. J Biol Chem. 2010. PMID: 20051519 Free PMC article.

5

Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.

Gregory KJ, Dong EN, Meiler J, Conn PJ. Gregory KJ, et al. Neuropharmacology. 2011 Jan;60(1):66-81. doi: 10.1016/j.neuropharm.2010.07.007. Epub 2010 Jul 14. Neuropharmacology. 2011. PMID: 20637216 Free PMC article. Review.

6

Allosteric modulation of metabotropic glutamate receptors.

Sheffler DJ, Gregory KJ, Rook JM, Conn PJ. Sheffler DJ, et al. Among authors: gregory kj. Adv Pharmacol. 2011;62:37-77. doi: 10.1016/B978-0-12-385952-5.00010-5. Adv Pharmacol. 2011. PMID: 21907906 Free PMC article. Review.

7

Overview of receptor allosterism.

Gregory KJ, Sexton PM, Christopoulos A. Gregory KJ, et al. Curr Protoc Pharmacol. 2010 Dec;Chapter 1:Unit 1.21. doi: 10.1002/0471141755.ph0121s51. Curr Protoc Pharmacol. 2010. PMID: 21935895

8

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.

Gregory KJ, Noetzel MJ, Rook JM, Vinson PN, Stauffer SR, Rodriguez AL, Emmitte KA, Zhou Y, Chun AC, Felts AS, Chauder BA, Lindsley CW, Niswender CM, Conn PJ. Gregory KJ, et al. Mol Pharmacol. 2012 Nov;82(5):860-75. doi: 10.1124/mol.112.080531. Epub 2012 Aug 3. Mol Pharmacol. 2012. PMID: 22863693 Free PMC article.

9

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.

Rook JM, Noetzel MJ, Pouliot WA, Bridges TM, Vinson PN, Cho HP, Zhou Y, Gogliotti RD, Manka JT, Gregory KJ, Stauffer SR, Dudek FE, Xiang Z, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ. Rook JM, et al. Among authors: gregory kj. Biol Psychiatry. 2013 Mar 15;73(6):501-9. doi: 10.1016/j.biopsych.2012.09.012. Epub 2012 Nov 7. Biol Psychiatry. 2013. PMID: 23140665 Free PMC article.

10

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.

Noetzel MJ, Gregory KJ, Vinson PN, Manka JT, Stauffer SR, Lindsley CW, Niswender CM, Xiang Z, Conn PJ. Noetzel MJ, et al. Among authors: gregory kj. Mol Pharmacol. 2013 Apr;83(4):835-47. doi: 10.1124/mol.112.082891. Epub 2013 Jan 24. Mol Pharmacol. 2013. PMID: 23348500 Free PMC article.

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