Zhu K - Search Results

1

Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation.

Jiang CS, Ge YX, Cheng ZQ, Song JL, Wang YY, Zhu K, Zhang H. Jiang CS, et al. Among authors: zhu k. J Comput Aided Mol Des. 2019 May;33(5):521-530. doi: 10.1007/s10822-019-00202-2. Epub 2019 Apr 15. J Comput Aided Mol Des. 2019. PMID: 30989573

2

Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening.

Meng F, Cheng S, Ding H, Liu S, Liu Y, Zhu K, Chen S, Lu J, Xie Y, Li L, Liu R, Shi Z, Zhou Y, Liu YC, Zheng M, Jiang H, Lu W, Liu H, Luo C. Meng F, et al. Among authors: zhu k. J Med Chem. 2015 Oct 22;58(20):8166-81. doi: 10.1021/acs.jmedchem.5b01154. Epub 2015 Sep 30. J Med Chem. 2015. PMID: 26390175

3

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.

Mao R, Shao J, Zhu K, Zhang Y, Ding H, Zhang C, Shi Z, Jiang H, Sun D, Duan W, Luo C. Mao R, et al. Among authors: zhu k. J Med Chem. 2017 Jul 27;60(14):6289-6304. doi: 10.1021/acs.jmedchem.7b00587. Epub 2017 Jul 12. J Med Chem. 2017. PMID: 28650658

4

Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods.

Zhu K, Jiang CS, Hu J, Liu X, Yan X, Tao H, Luo C, Zhang H. Zhu K, et al. Biochem Biophys Res Commun. 2018 Jan 1;495(1):721-727. doi: 10.1016/j.bbrc.2017.11.089. Epub 2017 Nov 14. Biochem Biophys Res Commun. 2018. PMID: 29154828

5

Phenolic bisabolane sesquiterpenoids from a Thai mangrove endophytic fungus, Aspergillus sp. xy02.

Wang P, Yu JH, Zhu K, Wang Y, Cheng ZQ, Jiang CS, Dai JG, Wu J, Zhang H. Wang P, et al. Among authors: zhu k. Fitoterapia. 2018 Jun;127:322-327. doi: 10.1016/j.fitote.2018.02.031. Epub 2018 Mar 12. Fitoterapia. 2018. PMID: 29544761

6

Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations.

Zhu K, Jiang C, Tao H, Liu J, Zhang H, Luo C. Zhu K, et al. Bioorg Med Chem Lett. 2018 May 15;28(9):1476-1483. doi: 10.1016/j.bmcl.2018.03.087. Epub 2018 Mar 30. Bioorg Med Chem Lett. 2018. PMID: 29628326

7

Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy.

Jiang CS, Zhuang CL, Zhu K, Zhang J, Muehlmann LA, Figueiró Longo JP, Azevedo RB, Zhang W, Meng N, Zhang H. Jiang CS, et al. Among authors: zhu k. J Enzyme Inhib Med Chem. 2018 Dec;33(1):833-841. doi: 10.1080/14756366.2018.1461856. J Enzyme Inhib Med Chem. 2018. PMID: 29693453 Free PMC article.

8

Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008.

Bao J, Zhai H, Zhu K, Yu JH, Zhang Y, Wang Y, Jiang CS, Zhang X, Zhang Y, Zhang H. Bao J, et al. Among authors: zhu k. Mar Drugs. 2018 May 22;16(5):174. doi: 10.3390/md16050174. Mar Drugs. 2018. PMID: 29786655 Free PMC article.

9

New Octadecanoid Enantiomers from the Whole Plants of Plantago depressa.

Song XQ, Zhu K, Yu JH, Zhang Q, Zhang Y, He F, Cheng ZQ, Jiang CS, Bao J, Zhang H. Song XQ, et al. Among authors: zhu k. Molecules. 2018 Jul 14;23(7):1723. doi: 10.3390/molecules23071723. Molecules. 2018. PMID: 30011919 Free PMC article.

10

Total Synthesis of Pulmonarin B and Design of Brominated Phenylacetic Acid/Tacrine Hybrids: Marine Pharmacophore Inspired Discovery of New ChE and Aβ Aggregation Inhibitors.

Cheng ZQ, Song JL, Zhu K, Zhang J, Jiang CS, Zhang H. Cheng ZQ, et al. Among authors: zhu k. Mar Drugs. 2018 Aug 21;16(9):293. doi: 10.3390/md16090293. Mar Drugs. 2018. PMID: 30134630 Free PMC article.

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