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Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1.
Harnoš J, Cañizal MCA, Jurásek M, Kumar J, Holler C, Schambony A, Hanáková K, Bernatík O, Zdráhal Z, Gömöryová K, Gybeľ T, Radaszkiewicz TW, Kravec M, Trantírek L, Ryneš J, Dave Z, Fernández-Llamazares AI, Vácha R, Tripsianes K, Hoffmann C, Bryja V. Harnoš J, et al. Among authors: hoffmann c. Nat Commun. 2019 Apr 18;10(1):1804. doi: 10.1038/s41467-019-09651-7. Nat Commun. 2019. PMID: 31000703 Free PMC article.
A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy.
Agnetta L, Kauk M, Canizal MCA, Messerer R, Holzgrabe U, Hoffmann C, Decker M. Agnetta L, et al. Among authors: hoffmann c. Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7282-7287. doi: 10.1002/anie.201701524. Epub 2017 May 16. Angew Chem Int Ed Engl. 2017. PMID: 28510314
Lack of beta-arrestin signaling in the absence of active G proteins.
Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E. Grundmann M, et al. Among authors: hoffmann c. Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3. Nat Commun. 2018. PMID: 29362459 Free PMC article.
Helix 8 is the essential structural motif of mechanosensitive GPCRs.
Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos Y Schnitzler M. Erdogmus S, et al. Among authors: hoffmann c. Nat Commun. 2019 Dec 19;10(1):5784. doi: 10.1038/s41467-019-13722-0. Nat Commun. 2019. PMID: 31857598 Free PMC article.
Structural insight into small molecule action on Frizzleds.
Kozielewicz P, Turku A, Bowin CF, Petersen J, Valnohova J, Cañizal MCA, Ono Y, Inoue A, Hoffmann C, Schulte G. Kozielewicz P, et al. Among authors: hoffmann c. Nat Commun. 2020 Jan 21;11(1):414. doi: 10.1038/s41467-019-14149-3. Nat Commun. 2020. PMID: 31964872 Free PMC article.
1,634 results