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Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.
Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B. Karahatay S, et al. Among authors: liu x. Cancer Lett. 2007 Oct 18;256(1):101-11. doi: 10.1016/j.canlet.2007.06.003. Epub 2007 Jul 9. Cancer Lett. 2007. PMID: 17619081 Free PMC article. Clinical Trial.
Involvement of sphingolipids in apoptin-induced cell killing.
Liu X, Zeidan YH, Elojeimy S, Holman DH, El-Zawahry AM, Guo GW, Bielawska A, Bielawski J, Szulc Z, Rubinchik S, Dong JY, Keane TE, Tavassoli M, Hannun YA, Norris JS. Liu X, et al. Mol Ther. 2006 Nov;14(5):627-36. doi: 10.1016/j.ymthe.2006.07.001. Epub 2006 Aug 22. Mol Ther. 2006. PMID: 16926120 Free article.
Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy.
Elojeimy S, Liu X, McKillop JC, El-Zawahry AM, Holman DH, Cheng JY, Meacham WD, Mahdy AE, Saad AF, Turner LS, Cheng J, A Day T, Dong JY, Bielawska A, Hannun YA, Norris JS. Elojeimy S, et al. Among authors: liu x. Mol Ther. 2007 Jul;15(7):1259-63. doi: 10.1038/sj.mt.6300167. Epub 2007 Apr 10. Mol Ther. 2007. PMID: 17426710 Free article.
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.
Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, Szulc ZM, Norris K, Zeidan YH, Hannun YA, Bielawska A, Norris JS. Holman DH, et al. Among authors: liu x. Cancer Chemother Pharmacol. 2008 Feb;61(2):231-42. doi: 10.1007/s00280-007-0465-0. Epub 2007 Apr 12. Cancer Chemother Pharmacol. 2008. PMID: 17429631
Molecular targeting of acid ceramidase: implications to cancer therapy.
Zeidan YH, Jenkins RW, Korman JB, Liu X, Obeid LM, Norris JS, Hannun YA. Zeidan YH, et al. Among authors: liu x. Curr Drug Targets. 2008 Aug;9(8):653-61. doi: 10.2174/138945008785132358. Curr Drug Targets. 2008. PMID: 18691012 Free PMC article. Review.
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.
Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, Keane TE, Taha MI, Hammouda HM, Norris JS, Liu X. Mahdy AE, et al. Among authors: liu x. Mol Ther. 2009 Mar;17(3):430-8. doi: 10.1038/mt.2008.281. Epub 2008 Dec 23. Mol Ther. 2009. PMID: 19107118 Free PMC article.
Synthesis and bioevaluation of omega-N-amino analogs of B13.
Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A. Bai A, et al. Among authors: liu x. Bioorg Med Chem. 2009 Mar 1;17(5):1840-8. doi: 10.1016/j.bmc.2009.01.057. Epub 2009 Jan 31. Bioorg Med Chem. 2009. PMID: 19217788 Free PMC article.
Novel omega-N-amino analogs of B13 (Class E) were designed, synthesized and tested as inhibitors of acid ceramidase (ACDase) and potential anticancer agents deprived of unwanted lysosomal destabilization and ACDase proteolytic degradation properties of LCL204 [Szulc, Z. M.; Mayro …
Novel omega-N-amino analogs of B13 (Class E) were designed, synthesized and tested as inhibitors of acid ceramidase (ACDase) and potential a …
137,858 results
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