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A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERRγ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer.
Singh TD, Song J, Kim J, Chin J, Ji HD, Lee JE, Lee SB, Yoon H, Yu JH, Kim SK, Yoon GS, Hwang H, Lee HW, Oh JM, Lee SW, Lee J, Choi HS, Na SY, Choi WI, Park YJ, Song YS, Kim YA, Lee IK, Cho SJ, Jeon YH. Singh TD, et al. Among authors: yoon h, yoon gs. Clin Cancer Res. 2019 Aug 15;25(16):5069-5081. doi: 10.1158/1078-0432.CCR-18-3007. Epub 2019 Apr 22. Clin Cancer Res. 2019. PMID: 31010838
Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor γ (ERRγ) Inverse Agonists.
Kim J, Woo SY, Im CY, Yoo EK, Lee S, Kim HJ, Hwang HJ, Cho JH, Lee WS, Yoon H, Kim S, Kwon OB, Hwang H, Kim KH, Jeon JH, Singh TD, Kim SW, Hwang SY, Choi HS, Lee IK, Kim SH, Jeon YH, Chin J, Cho SJ. Kim J, et al. Among authors: yoon h. J Med Chem. 2016 Nov 23;59(22):10209-10227. doi: 10.1021/acs.jmedchem.6b01204. Epub 2016 Nov 9. J Med Chem. 2016. PMID: 27805390
Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction.
Lee Y, Yoon H, Hwang SM, Shin MK, Lee JH, Oh M, Im SH, Song J, Lim HS. Lee Y, et al. Among authors: yoon h. J Am Chem Soc. 2017 Nov 15;139(45):16056-16059. doi: 10.1021/jacs.7b08972. Epub 2017 Nov 1. J Am Chem Soc. 2017. PMID: 29090910
Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
Kim J, Song J, Ji HD, Yoo EK, Lee JE, Lee SB, Oh JM, Lee S, Hwang JS, Yoon H, Kim DS, Lee SJ, Jeong M, Lee S, Kim KH, Choi HS, Lee SW, Park KG, Lee IK, Kim SH, Hwang H, Jeon YH, Chin J, Cho SJ. Kim J, et al. Among authors: yoon h. J Med Chem. 2019 Feb 28;62(4):1837-1858. doi: 10.1021/acs.jmedchem.8b01296. Epub 2019 Feb 4. J Med Chem. 2019. PMID: 30657313
An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Kim J, Hwang H, Yoon H, Lee JE, Oh JM, An H, Ji HD, Lee S, Cha E, Ma MJ, Kim DS, Lee SJ, Kadayat TM, Song J, Lee SW, Jeon JH, Park KG, Lee IK, Jeon YH, Chin J, Cho SJ. Kim J, et al. Among authors: yoon h. Eur J Med Chem. 2020 Nov 1;205:112501. doi: 10.1016/j.ejmech.2020.112501. Epub 2020 Jul 14. Eur J Med Chem. 2020. PMID: 32758860
Highly potent and selective PPARδ agonist reverses memory deficits in mouse models of Alzheimer's disease.
Kim HJ, Kim H, Song J, Hong JY, Lee EH, Londhe AM, Choi JW, Park SJ, Oh E, Yoon H, Hwang H, Hahn D, Jung K, Kwon S, Kadayat TM, Ma MJ, Joo J, Kim J, Bae JH, Hwang H, Pae AN, Cho SJ, Park JH, Chin J, Kang H, Park KD. Kim HJ, et al. Among authors: yoon h. Theranostics. 2024 Sep 16;14(16):6088-6108. doi: 10.7150/thno.96707. eCollection 2024. Theranostics. 2024. PMID: 39431021 Free PMC article.
Biomarkers.
Jeon JY, Lee H, Yoon H, Roh S, Ahn D. Jeon JY, et al. Among authors: yoon h. Alzheimers Dement. 2024 Dec;20 Suppl 2:e088486. doi: 10.1002/alz.088486. Alzheimers Dement. 2024. PMID: 39786029
Biomarkers.
Kim S, Wang SM, Kang DW, Um YH, Yoon HM, Lee S, Choe YS, Kim RE, Kim D, Lee CU, Lim HK. Kim S, et al. Among authors: yoon hm. Alzheimers Dement. 2024 Dec;20 Suppl 2:e088584. doi: 10.1002/alz.088584. Alzheimers Dement. 2024. PMID: 39784345
7,733 results