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Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.
Zhu L, Dattaroy D, Pham J, Wang L, Barella LF, Cui Y, Wilkins KJ, Roth BL, Hochgeschwender U, Matschinsky FM, Kaestner KH, Doliba NM, Wess J. Zhu L, et al. Among authors: roth bl. JCI Insight. 2019 Apr 23;5(10):e127994. doi: 10.1172/jci.insight.127994. JCI Insight. 2019. PMID: 31012868 Free PMC article.
Engineering GPCR signaling pathways with RASSLs.
Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Conklin BR, et al. Among authors: roth bl. Nat Methods. 2008 Aug;5(8):673-8. doi: 10.1038/nmeth.1232. Nat Methods. 2008. PMID: 18668035 Free PMC article. Review.
Engineered GPCRs as tools to modulate signal transduction.
Pei Y, Rogan SC, Yan F, Roth BL. Pei Y, et al. Among authors: roth bl. Physiology (Bethesda). 2008 Dec;23:313-21. doi: 10.1152/physiol.00025.2008. Physiology (Bethesda). 2008. PMID: 19074739 Free article. Review.
A chemical-genetic approach to study G protein regulation of beta cell function in vivo.
Guettier JM, Gautam D, Scarselli M, Ruiz de Azua I, Li JH, Rosemond E, Ma X, Gonzalez FJ, Armbruster BN, Lu H, Roth BL, Wess J. Guettier JM, et al. Among authors: roth bl. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19197-202. doi: 10.1073/pnas.0906593106. Epub 2009 Oct 26. Proc Natl Acad Sci U S A. 2009. PMID: 19858481 Free PMC article.
A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.
Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, Caron MG, Calakos N, Roth BL. Farrell MS, et al. Among authors: roth bl. Neuropsychopharmacology. 2013 Apr;38(5):854-62. doi: 10.1038/npp.2012.251. Epub 2012 Dec 5. Neuropsychopharmacology. 2013. PMID: 23303063 Free PMC article.
DREADD: a chemogenetic GPCR signaling platform.
Zhu H, Roth BL. Zhu H, et al. Among authors: roth bl. Int J Neuropsychopharmacol. 2014 Oct 31;18(1):pyu007. doi: 10.1093/ijnp/pyu007. Int J Neuropsychopharmacol. 2014. PMID: 25522378 Free PMC article.
545 results