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Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies.
Alexaki A, Hettiarachchi GK, Athey JC, Katneni UK, Simhadri V, Hamasaki-Katagiri N, Nanavaty P, Lin B, Takeda K, Freedberg D, Monroe D, McGill JR, Peters R, Kames JM, Holcomb DD, Hunt RC, Sauna ZE, Gelinas A, Janjic N, DiCuccio M, Bar H, Komar AA, Kimchi-Sarfaty C. Alexaki A, et al. Among authors: holcomb dd. Sci Rep. 2019 Oct 29;9(1):15449. doi: 10.1038/s41598-019-51984-2. Sci Rep. 2019. PMID: 31664102 Free PMC article.
A Single Synonymous Variant (c.354G>A [p.P118P]) in ADAMTS13 Confers Enhanced Specific Activity.
Hunt R, Hettiarachchi G, Katneni U, Hernandez N, Holcomb D, Kames J, Alnifaidy R, Lin B, Hamasaki-Katagiri N, Wesley A, Kafri T, Morris C, Bouché L, Panico M, Schiller T, Ibla J, Bar H, Ismail A, Morris H, Komar A, Kimchi-Sarfaty C. Hunt R, et al. Int J Mol Sci. 2019 Nov 15;20(22):5734. doi: 10.3390/ijms20225734. Int J Mol Sci. 2019. PMID: 31731663 Free PMC article.
Gene variants of coagulation related proteins that interact with SARS-CoV-2.
Holcomb D, Alexaki A, Hernandez N, Hunt R, Laurie K, Kames J, Hamasaki-Katagiri N, Komar AA, DiCuccio M, Kimchi-Sarfaty C. Holcomb D, et al. PLoS Comput Biol. 2021 Mar 17;17(3):e1008805. doi: 10.1371/journal.pcbi.1008805. eCollection 2021 Mar. PLoS Comput Biol. 2021. PMID: 33730015 Free PMC article.
Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design.
Kames J, Holcomb DD, Kimchi O, DiCuccio M, Hamasaki-Katagiri N, Wang T, Komar AA, Alexaki A, Kimchi-Sarfaty C. Kames J, et al. Among authors: holcomb dd. bioRxiv [Preprint]. 2020 Mar 31:2020.03.30.016832. doi: 10.1101/2020.03.30.016832. bioRxiv. 2020. Update in: Sci Rep. 2020 Sep 24;10(1):15643. doi: 10.1038/s41598-020-72533-2 PMID: 32511300 Free PMC article. Updated. Preprint.
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