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Phenotypic screening of the 'Kurz-box' of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus.
Nguyen LT, Kurz T, Preston S, Brueckmann H, Lungerich B, Herath HMPD, Koehler AV, Wang T, Skálová L, Jabbar A, Gasser RB. Nguyen LT, et al. Parasit Vectors. 2019 Apr 30;12(1):191. doi: 10.1186/s13071-019-3426-7. Parasit Vectors. 2019. PMID: 31039802 Free PMC article.
Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation.
Zajíčková M, Prchal L, Vokřál I, Nguyen LT, Kurz T, Gasser R, Bednářová K, Mičundová M, Lungerich B, Michel O, Skálová L. Zajíčková M, et al. Among authors: nguyen lt. Pharmaceutics. 2022 Mar 30;14(4):754. doi: 10.3390/pharmaceutics14040754. Pharmaceutics. 2022. PMID: 35456588 Free PMC article.
Environmental circulation of the anthelmintic drug albendazole affects expression and activity of resistance-related genes in the parasitic nematode Haemonchus contortus.
Dimunová D, Matoušková P, Navrátilová M, Nguyen LT, Ambrož M, Vokřál I, Szotáková B, Skálová L. Dimunová D, et al. Among authors: nguyen lt. Sci Total Environ. 2022 May 20;822:153527. doi: 10.1016/j.scitotenv.2022.153527. Epub 2022 Jan 29. Sci Total Environ. 2022. PMID: 35101480
Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites.
Stuchlíková LR, Matoušková P, Vokřál I, Lamka J, Szotáková B, Sečkařová A, Dimunová D, Nguyen LT, Várady M, Skálová L. Stuchlíková LR, et al. Among authors: nguyen lt. Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):50-58. doi: 10.1016/j.ijpddr.2018.01.005. Epub 2018 Jan 31. Int J Parasitol Drugs Drug Resist. 2018. PMID: 29414106 Free PMC article.
UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences.
Matoušková P, Lecová L, Laing R, Dimunová D, Vogel H, Raisová Stuchlíková L, Nguyen LT, Kellerová P, Vokřál I, Lamka J, Szotáková B, Várady M, Skálová L. Matoušková P, et al. Among authors: nguyen lt. Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):420-429. doi: 10.1016/j.ijpddr.2018.09.005. Epub 2018 Sep 26. Int J Parasitol Drugs Drug Resist. 2018. PMID: 30293057 Free PMC article.
The inhibitory effects of β-caryophyllene, β-caryophyllene oxide and α-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro.
Nguyen LT, Myslivečková Z, Szotáková B, Špičáková A, Lněničková K, Ambrož M, Kubíček V, Krasulová K, Anzenbacher P, Skálová L. Nguyen LT, et al. Chem Biol Interact. 2017 Dec 25;278:123-128. doi: 10.1016/j.cbi.2017.10.021. Epub 2017 Oct 23. Chem Biol Interact. 2017. PMID: 29074051
1,200 results