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Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.
Klotz L, Eschborn M, Lindner M, Liebmann M, Herold M, Janoschka C, Torres Garrido B, Schulte-Mecklenbeck A, Gross CC, Breuer J, Hundehege P, Posevitz V, Pignolet B, Nebel G, Glander S, Freise N, Austermann J, Wirth T, Campbell GR, Schneider-Hohendorf T, Eveslage M, Brassat D, Schwab N, Loser K, Roth J, Busch KB, Stoll M, Mahad DJ, Meuth SG, Turner T, Bar-Or A, Wiendl H. Klotz L, et al. Among authors: roth j. Sci Transl Med. 2019 May 1;11(490):eaao5563. doi: 10.1126/scitranslmed.aao5563. Sci Transl Med. 2019. PMID: 31043571 Clinical Trial.
Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity.
Liebmann M, Hucke S, Koch K, Eschborn M, Ghelman J, Chasan AI, Glander S, Schädlich M, Kuhlencord M, Daber NM, Eveslage M, Beyer M, Dietrich M, Albrecht P, Stoll M, Busch KB, Wiendl H, Roth J, Kuhlmann T, Klotz L. Liebmann M, et al. Among authors: roth j. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8017-E8026. doi: 10.1073/pnas.1721049115. Epub 2018 Aug 2. Proc Natl Acad Sci U S A. 2018. PMID: 30072431 Free PMC article.
S100-alarmins: potential therapeutic targets for arthritis.
Austermann J, Zenker S, Roth J. Austermann J, et al. Among authors: roth j. Expert Opin Ther Targets. 2017 Jul;21(7):739-751. doi: 10.1080/14728222.2017.1330411. Epub 2017 May 25. Expert Opin Ther Targets. 2017. PMID: 28494625 Review.
S100 proteins in rheumatic diseases.
Austermann J, Spiekermann C, Roth J. Austermann J, et al. Among authors: roth j. Nat Rev Rheumatol. 2018 Sep;14(9):528-541. doi: 10.1038/s41584-018-0058-9. Nat Rev Rheumatol. 2018. PMID: 30076385 Review.
Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8.
Fassl SK, Austermann J, Papantonopoulou O, Riemenschneider M, Xue J, Bertheloot D, Freise N, Spiekermann C, Witten A, Viemann D, Kirschnek S, Stoll M, Latz E, Schultze JL, Roth J, Vogl T. Fassl SK, et al. Among authors: roth j. J Immunol. 2015 Jan 15;194(2):575-83. doi: 10.4049/jimmunol.1401085. Epub 2014 Dec 10. J Immunol. 2015. PMID: 25505274 Clinical Trial.
4,903 results