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Page 1
Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-β-mediated IL-6 receptor suppression.
Wiegertjes R, Thielen NGM, van Caam APM, van Laar M, van Beuningen HM, Koenders MI, van Lent PLEM, van der Kraan PM, van de Loo FAJ, Blaney Davidson EN. Wiegertjes R, et al. Osteoarthritis Cartilage. 2021 May;29(5):773-782. doi: 10.1016/j.joca.2021.01.008. Epub 2021 Feb 20. Osteoarthritis Cartilage. 2021. PMID: 33617971 Free article.
Osteoarthritis-Related Inflammation Blocks TGF-β's Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region.
Thielen N, Neefjes M, Wiegertjes R, van den Akker G, Vitters E, van Beuningen H, Blaney Davidson E, Koenders M, van Lent P, van de Loo F, van Caam A, van der Kraan P. Thielen N, et al. Among authors: wiegertjes r. Int J Mol Sci. 2021 Jul 29;22(15):8124. doi: 10.3390/ijms22158124. Int J Mol Sci. 2021. PMID: 34360888 Free PMC article.
A three-dimensional model to study human synovial pathology.
Broeren MGA, Waterborg CEJ, Wiegertjes R, Thurlings RM, Koenders MI, Van Lent PLEM, Van der Kraan PM, Van de Loo FAJ. Broeren MGA, et al. Among authors: wiegertjes r. ALTEX. 2019;36(1):18-28. doi: 10.14573/altex.1804161. Epub 2018 Oct 9. ALTEX. 2019. PMID: 30303512 Free article.
A roadmap to target interleukin-6 in osteoarthritis.
Wiegertjes R, van de Loo FAJ, Blaney Davidson EN. Wiegertjes R, et al. Rheumatology (Oxford). 2020 Oct 1;59(10):2681-2694. doi: 10.1093/rheumatology/keaa248. Rheumatology (Oxford). 2020. PMID: 32691066 Free PMC article.
Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1.
Rudjord-Levann AM, Ye Z, Hafkenscheid L, Horn S, Wiegertjes R, Nielsen MAI, Song M, Mathiesen CBK, Stoop J, Stowell S, Straten PT, Leffler H, Vakhrushev SY, Dabelsteen S, Olsen JV, Wandall HH. Rudjord-Levann AM, et al. Among authors: wiegertjes r. iScience. 2023 May 27;26(7):106984. doi: 10.1016/j.isci.2023.106984. eCollection 2023 Jul 21. iScience. 2023. PMID: 37534161 Free PMC article.