Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.
Deb TB, Zuo AH, Wang Y, Barndt RJ, Cheema AK, Sengupta S, Coticchia CM, Johnson MD.
Deb TB, et al.
Am J Physiol Cell Physiol. 2011 May;300(5):C1139-54. doi: 10.1152/ajpcell.00167.2010. Epub 2011 Feb 16.
Am J Physiol Cell Physiol. 2011.
PMID: 21325639
Free PMC article.
We have recently described a novel role for pregnancy-upregulated non-ubiquitous calmodulin kinase (Pnck) in the induction of ligand-independent epidermal growth factor receptor (EGFR) degradation (Deb TB, Coticchia CM, Barndt R, Zuo H, Dickson RB, and Johnson MD. . …
We have recently described a novel role for pregnancy-upregulated non-ubiquitous calmodulin kinase (Pnck) in the induction of ligand- …