Arendse LB - Search Results

1

Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb).

Sturrock ED, Lubbe L, Cozier GE, Schwager SLU, Arowolo AT, Arendse LB, Belcher E, Acharya KR. Sturrock ED, et al. Among authors: arendse lb. Biochem J. 2019 May 31;476(10):1553-1570. doi: 10.1042/BCJ20190290. Biochem J. 2019. PMID: 31072910

2

Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.

Cozier GE, Arendse LB, Schwager SL, Sturrock ED, Acharya KR. Cozier GE, et al. Among authors: arendse lb. J Med Chem. 2018 Nov 21;61(22):10141-10154. doi: 10.1021/acs.jmedchem.8b01309. Epub 2018 Nov 7. J Med Chem. 2018. PMID: 30372620 Free article.

3

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure.

Arendse LB, Danser AHJ, Poglitsch M, Touyz RM, Burnett JC Jr, Llorens-Cortes C, Ehlers MR, Sturrock ED. Arendse LB, et al. Pharmacol Rev. 2019 Oct;71(4):539-570. doi: 10.1124/pr.118.017129. Pharmacol Rev. 2019. PMID: 31537750 Free PMC article. Review.

4

Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension.

Alves-Lopes R, Montezano AC, Neves KB, Harvey A, Rios FJ, Skiba DS, Arendse LB, Guzik TJ, Graham D, Poglitsch M, Sturrock E, Touyz RM. Alves-Lopes R, et al. Among authors: arendse lb. Hypertension. 2021 Sep;78(3):604-616. doi: 10.1161/HYPERTENSIONAHA.121.17041. Epub 2021 Jul 26. Hypertension. 2021. PMID: 34304582 Free PMC article.

5

Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.

Arendse LB, Cozier GE, Eyermann CJ, Basarab GS, Schwager SL, Chibale K, Acharya KR, Sturrock ED. Arendse LB, et al. J Med Chem. 2022 Feb 24;65(4):3371-3387. doi: 10.1021/acs.jmedchem.1c01924. Epub 2022 Feb 3. J Med Chem. 2022. PMID: 35113565

6

Combining in silico protein stability calculations with structure-function relationships to explore the effect of polymorphic variation on cytochrome P450 drug metabolism.

Arendse L, Blundell TL, Blackburn J. Arendse L, et al. Curr Drug Metab. 2013 Sep;14(7):745-63. doi: 10.2174/13892002113149990097. Curr Drug Metab. 2013. PMID: 23826828

7

Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors.

Fienberg S, Eyermann CJ, Arendse LB, Basarab GS, McPhail JA, Burke JE, Chibale K. Fienberg S, et al. Among authors: arendse lb. ACS Infect Dis. 2020 Nov 13;6(11):3048-3063. doi: 10.1021/acsinfecdis.0c00566. Epub 2020 Oct 9. ACS Infect Dis. 2020. PMID: 32966036

8

Effects of polymorphic variation on the thermostability of heterogenous populations of CYP3A4 and CYP2C9 enzymes in solution.

Arendse LB, Blackburn JM. Arendse LB, et al. Sci Rep. 2018 Aug 8;8(1):11876. doi: 10.1038/s41598-018-30195-1. Sci Rep. 2018. PMID: 30089838 Free PMC article.

9

Developing kinase inhibitors for malaria: an opportunity or liability?

Mogwera KSP, Chibale K, Arendse LB. Mogwera KSP, et al. Among authors: arendse lb. Trends Parasitol. 2023 Sep;39(9):720-731. doi: 10.1016/j.pt.2023.06.001. Epub 2023 Jun 27. Trends Parasitol. 2023. PMID: 37385921 Review.

10

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.

Vanaerschot M, Murithi JM, Pasaje CFA, Ghidelli-Disse S, Dwomoh L, Bird M, Spottiswoode N, Mittal N, Arendse LB, Owen ES, Wicht KJ, Siciliano G, Bösche M, Yeo T, Kumar TRS, Mok S, Carpenter EF, Giddins MJ, Sanz O, Ottilie S, Alano P, Chibale K, Llinás M, Uhlemann AC, Delves M, Tobin AB, Doerig C, Winzeler EA, Lee MCS, Niles JC, Fidock DA. Vanaerschot M, et al. Among authors: arendse lb. Cell Chem Biol. 2020 Jul 16;27(7):806-816.e8. doi: 10.1016/j.chembiol.2020.04.001. Epub 2020 Apr 30. Cell Chem Biol. 2020. PMID: 32359426 Free PMC article.

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