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Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.
McDonald PC, Chafe SC, Brown WS, Saberi S, Swayampakula M, Venkateswaran G, Nemirovsky O, Gillespie JA, Karasinska JM, Kalloger SE, Supuran CT, Schaeffer DF, Bashashati A, Shah SP, Topham JT, Yapp DT, Li J, Renouf DJ, Stanger BZ, Dedhar S. McDonald PC, et al. Among authors: brown ws. Gastroenterology. 2019 Sep;157(3):823-837. doi: 10.1053/j.gastro.2019.05.004. Epub 2019 May 9. Gastroenterology. 2019. PMID: 31078621 Free article.
Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.
Chafe SC, Vizeacoumar FS, Venkateswaran G, Nemirovsky O, Awrey S, Brown WS, McDonald PC, Carta F, Metcalfe A, Karasinska JM, Huang L, Muthuswamy SK, Schaeffer DF, Renouf DJ, Supuran CT, Vizeacoumar FJ, Dedhar S. Chafe SC, et al. Among authors: brown ws. Sci Adv. 2021 Aug 27;7(35):eabj0364. doi: 10.1126/sciadv.abj0364. Print 2021 Aug. Sci Adv. 2021. PMID: 34452919 Free PMC article.
Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis.
Lee YC, Jin JK, Cheng CJ, Huang CF, Song JH, Huang M, Brown WS, Zhang S, Yu-Lee LY, Yeh ET, McIntyre BW, Logothetis CJ, Gallick GE, Lin SH. Lee YC, et al. Among authors: brown ws. Mol Cancer Res. 2013 Apr;11(4):405-17. doi: 10.1158/1541-7786.MCR-12-0551. Epub 2013 Jan 21. Mol Cancer Res. 2013. PMID: 23339185 Free PMC article.
The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells.
Fiorcari S, Brown WS, McIntyre BW, Estrov Z, Maffei R, O'Brien S, Sivina M, Hoellenriegel J, Wierda WG, Keating MJ, Ding W, Kay NE, Lannutti BJ, Marasca R, Burger JA. Fiorcari S, et al. Among authors: brown ws. PLoS One. 2013 Dec 23;8(12):e83830. doi: 10.1371/journal.pone.0083830. eCollection 2013. PLoS One. 2013. PMID: 24376763 Free PMC article.
2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1.
Carreño R, Brown WS, Li D, Hernandez JA, Wang Y, Kim TK, Craft JW Jr, Komanduri KV, Radvanyi LG, Hwu P, Molldrem JJ, Legge GB, McIntyre BW, Ma Q. Carreño R, et al. Among authors: brown ws. J Biol Chem. 2010 Oct 22;285(43):32860-32868. doi: 10.1074/jbc.M110.111591. Epub 2010 Aug 19. J Biol Chem. 2010. PMID: 20724473 Free PMC article.
Adaptive behavior in primary agenesis of the corpus callosum.
Miller JS, Brown WS, Mangum RW, Nolty AAT, Paul LK. Miller JS, et al. Among authors: brown ws. Res Dev Disabil. 2024 Nov;154:104862. doi: 10.1016/j.ridd.2024.104862. Epub 2024 Oct 25. Res Dev Disabil. 2024. PMID: 39454245
191 results