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Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization.
Jiang M, Peng L, Yang K, Wang T, Yan X, Jiang T, Xu J, Qi J, Zhou H, Qian N, Zhou Q, Chen B, Xu X, Deng L, Yang C. Jiang M, et al. Among authors: chen b. J Med Chem. 2019 Jun 13;62(11):5370-5381. doi: 10.1021/acs.jmedchem.8b02027. Epub 2019 May 22. J Med Chem. 2019. PMID: 31082234
The effects of tranylcypromine on osteoclastogenesis in vitro and in vivo.
Liu Z, Yang K, Yan X, Wang T, Jiang T, Zhou Q, Qi J, Qian N, Zhou H, Chen B, Huang P, Guo L, Zhang X, Xu X, Jiang M, Deng L. Liu Z, et al. Among authors: chen b. FASEB J. 2019 Sep;33(9):9828-9841. doi: 10.1096/fj.201802242RR. Epub 2019 Jul 10. FASEB J. 2019. PMID: 31291555
The subsequent study revealed that TCP inhibited osteoclastogenesis-related genes in a time-dependent manner through protein kinase B (AKT)-mediated mechanism followed by the nuclear factor of activated T cells, cytoplasmic 1 (NFATc1)-c-fos pathway. ...-Liu, Z., Yang, K., …
The subsequent study revealed that TCP inhibited osteoclastogenesis-related genes in a time-dependent manner through protein kinase B …
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