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Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon.
DiCello JJ, Rajasekhar P, Eriksson EM, Saito A, Gondin AB, Veldhuis NA, Canals M, Carbone SE, Poole DP. DiCello JJ, et al. Among authors: saito a. Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G79-G89. doi: 10.1152/ajpgi.00085.2019. Epub 2019 May 15. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 31091149 Free article.
Inflammation-associated changes in DOR expression and function in the mouse colon.
DiCello JJ, Saito A, Rajasekhar P, Eriksson EM, McQuade RM, Nowell CJ, Sebastian BW, Fichna J, Veldhuis NA, Canals M, Bunnett NW, Carbone SE, Poole DP. DiCello JJ, et al. Among authors: saito a. Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1;315(4):G544-G559. doi: 10.1152/ajpgi.00025.2018. Epub 2018 Jun 21. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 29927325 Free PMC article.
Agonist-dependent development of delta opioid receptor tolerance in the colon.
DiCello JJ, Saito A, Rajasekhar P, Sebastian BW, McQuade RM, Gondin AB, Veldhuis NA, Canals M, Carbone SE, Poole DP. DiCello JJ, et al. Among authors: saito a. Cell Mol Life Sci. 2019 Aug;76(15):3033-3050. doi: 10.1007/s00018-019-03077-6. Epub 2019 Mar 23. Cell Mol Life Sci. 2019. PMID: 30904952 Free PMC article.
Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon.
DiCello JJ, Carbone SE, Saito A, Rajasekhar P, Ceredig RA, Pham V, Valant C, Christopoulos A, Veldhuis NA, Canals M, Massotte D, Poole DP. DiCello JJ, et al. Among authors: saito a. Cell Mol Gastroenterol Hepatol. 2020;9(3):465-483. doi: 10.1016/j.jcmgh.2019.11.006. Epub 2019 Nov 20. Cell Mol Gastroenterol Hepatol. 2020. PMID: 31759144 Free PMC article.
Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders.
DiCello JJ, Carbone SE, Saito A, Pham V, Szymaszkiewicz A, Gondin AB, Alvi S, Marique K, Shenoy P, Veldhuis NA, Fichna J, Canals M, Christopoulos A, Valant C, Poole DP. DiCello JJ, et al. Among authors: saito a. Am J Physiol Gastrointest Liver Physiol. 2022 Jan 1;322(1):G66-G78. doi: 10.1152/ajpgi.00297.2021. Epub 2021 Nov 10. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 34755545 Free article.
TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility.
Rajasekhar P, Carbone SE, Johnston ST, Nowell CJ, Wiklendt L, Crampin EJ, She Y, DiCello JJ, Saito A, Sorensen L, Nguyen T, Lee KM, Hamilton JA, King SK, Eriksson EM, Spencer NJ, Gulbransen BD, Veldhuis NA, Poole DP. Rajasekhar P, et al. Among authors: saito a. bioRxiv [Preprint]. 2024 Jan 11:2024.01.09.574831. doi: 10.1101/2024.01.09.574831. bioRxiv. 2024. PMID: 38260314 Free PMC article. Preprint.
Gut Analysis Toolbox - automating quantitative analysis of enteric neurons.
Sorensen L, Humenick A, Poon SSB, Han MN, Mahdavian NS, Rowe MC, Hamnett R, Gómez-de-Mariscal E, Neckel PH, Saito A, Mutunduwe K, Glennan C, Haase R, McQuade RM, Foong JPP, Brookes SJH, Kaltschmidt JA, Muñoz-Barrutia A, King SK, Veldhuis NA, Carbone SE, Poole DP, Rajasekhar P. Sorensen L, et al. Among authors: saito a. J Cell Sci. 2024 Oct 15;137(20):jcs261950. doi: 10.1242/jcs.261950. Epub 2024 Oct 30. J Cell Sci. 2024. PMID: 39219476 Free PMC article.
Efficacy of tranilast in preventing exacerbating cardiac function and death from heart failure in muscular dystrophy patients with advanced-stage heart failure: a single-arm, open-label, multicenter study.
Matsumura T, Fukudome T, Motoyoshi Y, Nakamura A, Kuru S, Segawa K, Kitao R, Watanabe C, Tamura T, Takahashi T, Hashimoto H, Sekimizu M, Saito AM, Asakura M, Kimura K, Iwata Y. Matsumura T, et al. Among authors: saito am. Orphanet J Rare Dis. 2025 Jan 9;20(1):13. doi: 10.1186/s13023-025-03538-1. Orphanet J Rare Dis. 2025. PMID: 39789553
4,579 results