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Page 1
PI3 kinase alpha and delta promote hematopoietic stem cell activation.
Hemmati S, Sinclair T, Tong M, Bartholdy B, Okabe RO, Ames K, Ostrodka L, Haque T, Kaur I, Mills TS, Agarwal A, Pietras EM, Zhao JJ, Roberts TM, Gritsman K. Hemmati S, et al. Among authors: okabe ro. JCI Insight. 2019 May 23;5(13):e125832. doi: 10.1172/jci.insight.125832. JCI Insight. 2019. PMID: 31120863 Free PMC article.
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.
Mullally A, Lane SW, Ball B, Megerdichian C, Okabe R, Al-Shahrour F, Paktinat M, Haydu JE, Housman E, Lord AM, Wernig G, Kharas MG, Mercher T, Kutok JL, Gilliland DG, Ebert BL. Mullally A, et al. Cancer Cell. 2010 Jun 15;17(6):584-96. doi: 10.1016/j.ccr.2010.05.015. Cancer Cell. 2010. PMID: 20541703 Free PMC article.
Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α.
Gritsman K, Yuzugullu H, Von T, Yan H, Clayton L, Fritsch C, Maira SM, Hollingworth G, Choi C, Khandan T, Paktinat M, Okabe RO, Roberts TM, Zhao JJ. Gritsman K, et al. Among authors: okabe ro. J Clin Invest. 2014 Apr;124(4):1794-809. doi: 10.1172/JCI69927. Epub 2014 Feb 24. J Clin Invest. 2014. PMID: 24569456 Free PMC article.
Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms.
Gurska LM, Okabe R, Schurer A, Tong MM, Soto M, Choi D, Ames K, Glushakow-Smith S, Montoya A, Tein E, Miles LA, Cheng H, Hankey-Giblin P, Levine RL, Goel S, Halmos B, Gritsman K. Gurska LM, et al. Clin Cancer Res. 2023 Mar 1;29(5):943-956. doi: 10.1158/1078-0432.CCR-22-1763. Clin Cancer Res. 2023. PMID: 36537918 Free PMC article.
MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.
Taggart J, Ho TC, Amin E, Xu H, Barlowe TS, Perez AR, Durham BH, Tivnan P, Okabe R, Chow A, Vu L, Park SM, Prieto C, Famulare C, Patel M, Lengner CJ, Verma A, Roboz G, Guzman M, Klimek VM, Abdel-Wahab O, Leslie C, Nimer SD, Kharas MG. Taggart J, et al. Nat Commun. 2016 Feb 22;7:10739. doi: 10.1038/ncomms10739. Nat Commun. 2016. PMID: 26898884 Free PMC article.
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, Morgan K, Tam W, Paktinat M, Okabe R, Gozo M, Einhorn W, Lane SW, Scholl C, Fröhling S, Fleming M, Ebert BL, Gilliland DG, Jaenisch R, Daley GQ. Kharas MG, et al. Nat Med. 2010 Aug;16(8):903-8. doi: 10.1038/nm.2187. Epub 2010 Jul 8. Nat Med. 2010. PMID: 20616797 Free PMC article.
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