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Cladophorol-A is an inhibitor of cyclic GMP-AMP synthase.
Kissai M, Chin EN, Martínez-Peña F, Sulpizio A, Stout EP, Usui I, Barmare F, Sanchez B, Esquenazi E, Stanfield RL, Wilson IA, Lairson LL. Kissai M, et al. Bioorg Med Chem Lett. 2025 Jan 1;115:130007. doi: 10.1016/j.bmcl.2024.130007. Epub 2024 Nov 7. Bioorg Med Chem Lett. 2025. PMID: 39521150
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Chin EN, Yu C, Vartabedian VF, Jia Y, Kumar M, Gamo AM, Vernier W, Ali SH, Kissai M, Lazar DC, Nguyen N, Pereira LE, Benish B, Woods AK, Joseph SB, Chu A, Johnson KA, Sander PN, Martínez-Peña F, Hampton EN, Young TS, Wolan DW, Chatterjee AK, Schultz PG, Petrassi HM, Teijaro JR, Lairson LL. Chin EN, et al. Among authors: kissai m. Science. 2020 Aug 21;369(6506):993-999. doi: 10.1126/science.abb4255. Science. 2020. PMID: 32820126