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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB); Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kaw… See abstract for full author list ➔ van der Lee SJ, et al. Among authors: jeune b. Acta Neuropathol. 2019 Aug;138(2):237-250. doi: 10.1007/s00401-019-02026-8. Epub 2019 May 27. Acta Neuropathol. 2019. PMID: 31131421 Free PMC article.
Do children of long-lived parents age more successfully?
Frederiksen H, McGue M, Jeune B, Gaist D, Nybo H, Skytthe A, Vaupel JW, Christensen K. Frederiksen H, et al. Among authors: jeune b. Epidemiology. 2002 May;13(3):334-9. doi: 10.1097/00001648-200205000-00015. Epidemiology. 2002. PMID: 11964936
Reproduction life history and hip fractures.
Petersen HC, Jeune B, Vaupel JW, Christensen K. Petersen HC, et al. Among authors: jeune b. Ann Epidemiol. 2002 May;12(4):257-63. doi: 10.1016/s1047-2797(01)00275-7. Ann Epidemiol. 2002. PMID: 11988414
Influence of environmental factors on facial ageing.
Rexbye H, Petersen I, Johansens M, Klitkou L, Jeune B, Christensen K. Rexbye H, et al. Among authors: jeune b. Age Ageing. 2006 Mar;35(2):110-5. doi: 10.1093/ageing/afj031. Epub 2006 Jan 11. Age Ageing. 2006. PMID: 16407433
Exceptional longevity does not result in excessive levels of disability.
Christensen K, McGue M, Petersen I, Jeune B, Vaupel JW. Christensen K, et al. Among authors: jeune b. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13274-9. doi: 10.1073/pnas.0804931105. Epub 2008 Aug 18. Proc Natl Acad Sci U S A. 2008. PMID: 18711139 Free PMC article.
252 results