Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators.
Hepnarova V, Muckova L, Ring A, Pejchal J, Herman D, Misik J, Hrabinova M, Jun D, Soukup O.
Hepnarova V, et al. Among authors: ring a.
Toxicol Appl Pharmacol. 2019 Nov 15;383:114776. doi: 10.1016/j.taap.2019.114776. Epub 2019 Oct 17.
Toxicol Appl Pharmacol. 2019.
PMID: 31629733
The major function of compounds with an oxime moiety attached to a quarternary nitrogen pyridinium ring is to reactivate acetylcholinesterase inhibited by organophosphorus agent (OP). ...However, a weak antimuscarinic activity in case of LuH-6 and a we …
The major function of compounds with an oxime moiety attached to a quarternary nitrogen pyridinium ring is to reactivate acety …