Hosokawa M - Search Results

1

Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases.

Mizoi K, Takahashi M, Sakai S, Ogihara T, Haba M, Hosokawa M. Mizoi K, et al. Among authors: hosokawa m. Xenobiotica. 2020 Mar;50(3):261-269. doi: 10.1080/00498254.2019.1625083. Epub 2019 Jun 19. Xenobiotica. 2020. PMID: 31173561

2

Investigation of the chiral recognition ability of human carboxylesterase 1 using indomethacin esters.

Takahashi M, Takani D, Haba M, Hosokawa M. Takahashi M, et al. Among authors: hosokawa m. Chirality. 2020 Jan;32(1):73-80. doi: 10.1002/chir.23141. Epub 2019 Nov 6. Chirality. 2020. PMID: 31693270

3

Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase.

Takahashi M, Hirota I, Nakano T, Kotani T, Takani D, Shiratori K, Choi Y, Haba M, Hosokawa M. Takahashi M, et al. Among authors: hosokawa m. Drug Metab Pharmacokinet. 2021 Jun;38:100391. doi: 10.1016/j.dmpk.2021.100391. Epub 2021 Mar 25. Drug Metab Pharmacokinet. 2021. PMID: 33872946

4

Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases.

Mizoi K, Takahashi M, Haba M, Hosokawa M. Mizoi K, et al. Among authors: hosokawa m. Bioorg Med Chem Lett. 2016 Feb 1;26(3):921-923. doi: 10.1016/j.bmcl.2015.12.069. Epub 2015 Dec 19. Bioorg Med Chem Lett. 2016. PMID: 26750256

5

Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1.

Takahashi M, Ogawa T, Kashiwagi H, Fukushima F, Yoshitsugu M, Haba M, Hosokawa M. Takahashi M, et al. Among authors: hosokawa m. Bioorg Med Chem Lett. 2018 Apr 1;28(6):997-1000. doi: 10.1016/j.bmcl.2018.02.035. Epub 2018 Feb 21. Bioorg Med Chem Lett. 2018. PMID: 29503023

6

Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1.

Takahashi M, Lee YJ, Kanayama T, Kondo Y, Nishio K, Mukai K, Haba M, Hosokawa M. Takahashi M, et al. Among authors: hosokawa m. Eur J Pharm Sci. 2020 Sep 1;152:105455. doi: 10.1016/j.ejps.2020.105455. Epub 2020 Jul 3. Eur J Pharm Sci. 2020. PMID: 32629019

7

Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase.

Takahashi M, Uehara T, Nonaka M, Minagawa Y, Yamazaki R, Haba M, Hosokawa M. Takahashi M, et al. Among authors: hosokawa m. Eur J Pharm Sci. 2019 Apr 30;132:125-131. doi: 10.1016/j.ejps.2019.03.009. Epub 2019 Mar 14. Eur J Pharm Sci. 2019. PMID: 30878380

8

Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death.

Mimori S, Kawada K, Saito R, Takahashi M, Mizoi K, Okuma Y, Hosokawa M, Kanzaki T. Mimori S, et al. Among authors: hosokawa m. Biochem Biophys Res Commun. 2019 Oct 1;517(4):623-628. doi: 10.1016/j.bbrc.2019.07.074. Epub 2019 Aug 1. Biochem Biophys Res Commun. 2019. PMID: 31378367

9

A new methodology for functionalization at the 3-position of indoles by a combination of boron Lewis acid with nitriles.

Mizoi K, Mashima Y, Kawashima Y, Takahashi M, Mimori S, Hosokawa M, Murakami Y, Hamana H. Mizoi K, et al. Among authors: hosokawa m. Chem Pharm Bull (Tokyo). 2015;63(7):538-45. doi: 10.1248/cpb.c15-00157. Chem Pharm Bull (Tokyo). 2015. PMID: 26133069 Free article.

10

Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissues.

Yamada T, Hosokawa M, Satoh T, Moroo I, Takahashi M, Akatsu H, Yamamoto T. Yamada T, et al. Among authors: hosokawa m. Brain Res. 1994 Sep 26;658(1-2):163-7. doi: 10.1016/s0006-8993(09)90022-1. Brain Res. 1994. PMID: 7834338

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