Lagrutta A - Search Results

1

HiPSC-CMs from different sex and ethnic origin donors exhibit qualitatively different responses to several classes of pharmacological challenges.

Zeng H, Wang J, Clouse H, Lagrutta A, Sannajust F. Zeng H, et al. Among authors: lagrutta a. J Pharmacol Toxicol Methods. 2019 Sep-Oct;99:106598. doi: 10.1016/j.vascn.2019.106598. Epub 2019 Jun 12. J Pharmacol Toxicol Methods. 2019. PMID: 31201864

2

Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes.

Zeng H, Roman MI, Lis E, Lagrutta A, Sannajust F. Zeng H, et al. Among authors: lagrutta a. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:217-22. doi: 10.1016/j.vascn.2016.05.009. Epub 2016 May 21. J Pharmacol Toxicol Methods. 2016. PMID: 27222351

3

Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment.

Zhang X, Guo L, Zeng H, White SL, Furniss M, Balasubramanian B, Lis E, Lagrutta A, Sannajust F, Zhao LL, Xi B, Wang X, Davis M, Abassi YA. Zhang X, et al. Among authors: lagrutta a. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:201-16. doi: 10.1016/j.vascn.2016.06.004. Epub 2016 Jun 7. J Pharmacol Toxicol Methods. 2016. PMID: 27282640

4

Response of human induced pluripotent stem cell-derived cardiomyocytes to several pharmacological agents when intrinsic syncytial pacing is overcome by acute external stimulation.

Zeng H, Balasubramanian B, Lagrutta A, Sannajust F. Zeng H, et al. Among authors: lagrutta a. J Pharmacol Toxicol Methods. 2018 May-Jun;91:18-26. doi: 10.1016/j.vascn.2017.12.004. Epub 2018 Jan 10. J Pharmacol Toxicol Methods. 2018. PMID: 29330131

5

Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation.

Zeng H, Wang J, Clouse H, Lagrutta A, Sannajust F. Zeng H, et al. Among authors: lagrutta a. Toxicol Sci. 2019 Feb 1;167(2):573-580. doi: 10.1093/toxsci/kfy264. Toxicol Sci. 2019. PMID: 30365015

6

[No title available]

[No authors listed] [No authors listed] PMID: 31962942

7

Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells.

Lagrutta A, Zeng H, Imredy J, Balasubramanian B, Dech S, Lis E, Wang J, Zhai J, DeGeorge J, Sannajust F. Lagrutta A, et al. Toxicol Appl Pharmacol. 2016 Oct 1;308:66-76. doi: 10.1016/j.taap.2016.08.006. Epub 2016 Aug 9. Toxicol Appl Pharmacol. 2016. PMID: 27520758

8

Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.

Lu HR, Zeng H, Kettenhofen R, Guo L, Kopljar I, van Ammel K, Tekle F, Teisman A, Zhai J, Clouse H, Pierson J, Furniss M, Lagrutta A, Sannajust F, Gallacher DJ. Lu HR, et al. Among authors: lagrutta a. Toxicol Sci. 2019 Aug 1;170(2):345-356. doi: 10.1093/toxsci/kfz102. Toxicol Sci. 2019. PMID: 31020317 Free PMC article.

9

Human-induced pluripotent stem cell-derived cardiomyocytes have limited I_Ks for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker.

Zeng H, Wang J, Clouse H, Lagrutta A, Sannajust F. Zeng H, et al. Among authors: lagrutta a. JRSM Cardiovasc Dis. 2019 Jun 5;8:2048004019854919. doi: 10.1177/2048004019854919. eCollection 2019 Jan-Dec. JRSM Cardiovasc Dis. 2019. PMID: 31217965 Free PMC article.

10

Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry.

Lagrutta A, Regan CP, Zeng H, Imredy JP, Koeplinger K, Morissette P, Liu L, Wollenberg G, Brynczka C, Lebrón J, DeGeorge J, Sannajust F. Lagrutta A, et al. Sci Rep. 2017 Mar 22;7:44820. doi: 10.1038/srep44820. Sci Rep. 2017. PMID: 28327633 Free PMC article.

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