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A single-nucleotide resolution capillary gel electrophoresis workflow for poly(A) tail characterization in the development of mRNA therapeutics and vaccines.
Di Grandi D, Dayeh DM, Kaur K, Chen Y, Henderson S, Moon Y, Bhowmick A, Ihnat PM, Fu Y, Muthusamy K, Palackal N, Pyles EA. Di Grandi D, et al. Among authors: pyles ea. J Pharm Biomed Anal. 2023 Nov 30;236:115692. doi: 10.1016/j.jpba.2023.115692. Epub 2023 Sep 2. J Pharm Biomed Anal. 2023. PMID: 37696189 Free article.
Comparison of capillary electrophoresis-based methods for the analytical characterization of purity and stability of in vitro transcribed mRNA.
Mantri P, Juneja B, Henderson S, Koufos E, Moon Y, Dayeh DM, Di Grandi D, Fu Y, Muthusamy K, Ihnat PM, Palackal N, Pyles EA. Mantri P, et al. Among authors: pyles ea. J Pharm Biomed Anal. 2024 Oct 15;249:116352. doi: 10.1016/j.jpba.2024.116352. Epub 2024 Jul 14. J Pharm Biomed Anal. 2024. PMID: 39029354 Free article.
A Biparatopic Antibody That Modulates MET Trafficking Exhibits Enhanced Efficacy Compared with Parental Antibodies in MET-Driven Tumor Models.
DaSilva JO, Yang K, Perez Bay AE, Andreev J, Ngoi P, Pyles E, Franklin MC, Dudgeon D, Rafique A, Dore A, Delfino FJ, Potocky TB, Babb R, Chen G, MacDonald D, Olson WC, Thurston G, Daly C. DaSilva JO, et al. Among authors: pyles e. Clin Cancer Res. 2020 Mar 15;26(6):1408-1419. doi: 10.1158/1078-0432.CCR-19-2428. Epub 2019 Dec 17. Clin Cancer Res. 2020. PMID: 31848185
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade.
Rudge JS, Holash J, Hylton D, Russell M, Jiang S, Leidich R, Papadopoulos N, Pyles EA, Torri A, Wiegand SJ, Thurston G, Stahl N, Yancopoulos GD. Rudge JS, et al. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18363-70. doi: 10.1073/pnas.0708865104. Epub 2007 Nov 13. Proc Natl Acad Sci U S A. 2007. PMID: 18000042 Free PMC article.
28 results