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3-O-Methyl-Alkylgallates Inhibit Fatty Acid Desaturation in Mycobacterium tuberculosis.
Rehberg N, Omeje E, Ebada SS, van Geelen L, Liu Z, Sureechatchayan P, Kassack MU, Ioerger TR, Proksch P, Kalscheuer R. Rehberg N, et al. Among authors: ioerger tr. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00136-19. doi: 10.1128/AAC.00136-19. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31209015 Free PMC article.
Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.
Wang F, Jain P, Gulten G, Liu Z, Feng Y, Ganesula K, Motiwala AS, Ioerger TR, Alland D, Vilchèze C, Jacobs WR Jr, Sacchettini JC. Wang F, et al. Among authors: ioerger tr. Antimicrob Agents Chemother. 2010 Sep;54(9):3776-82. doi: 10.1128/AAC.00453-10. Epub 2010 Jun 21. Antimicrob Agents Chemother. 2010. PMID: 20566771 Free PMC article.
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.
Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE 3rd, Sherman DR, Parish T, Sacchettini JC. Ioerger TR, et al. PLoS One. 2013 Sep 23;8(9):e75245. doi: 10.1371/journal.pone.0075245. eCollection 2013. PLoS One. 2013. PMID: 24086479 Free PMC article.
A novel antimycobacterial compound acts as an intracellular iron chelator.
Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ. Dragset MS, et al. Among authors: ioerger tr. Antimicrob Agents Chemother. 2015 Apr;59(4):2256-64. doi: 10.1128/AAC.05114-14. Epub 2015 Feb 2. Antimicrob Agents Chemother. 2015. PMID: 25645825 Free PMC article.
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.
Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR. Palencia A, et al. Among authors: ioerger tr. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. Print 2016 Oct. Antimicrob Agents Chemother. 2016. PMID: 27503647 Free PMC article.
Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis.
Koliwer-Brandl H, Syson K, van de Weerd R, Chandra G, Appelmelk B, Alber M, Ioerger TR, Jacobs WR Jr, Geurtsen J, Bornemann S, Kalscheuer R. Koliwer-Brandl H, et al. Among authors: ioerger tr. PLoS Pathog. 2016 Aug 11;12(8):e1005768. doi: 10.1371/journal.ppat.1005768. eCollection 2016 Aug. PLoS Pathog. 2016. PMID: 27513637 Free PMC article.
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR Jr, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R. Korte J, et al. Among authors: ioerger tr. PLoS Pathog. 2016 Dec 9;12(12):e1006043. doi: 10.1371/journal.ppat.1006043. eCollection 2016 Dec. PLoS Pathog. 2016. PMID: 27936238 Free PMC article.
168 results