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Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine.
van Andel L, Zhang Z, Lu S, Kansra V, Agarwal S, Hughes L, Tibben MM, Gebretensae A, Rosing H, Schellens JHM, Beijnen JH. van Andel L, et al. Among authors: lu s. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:14-21. doi: 10.1016/j.jchromb.2016.11.020. Epub 2016 Nov 19. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 27898364
Human mass balance study and metabolite profiling of 14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer.
van Andel L, Zhang Z, Lu S, Kansra V, Agarwal S, Hughes L, Tibben MM, Gebretensae A, Lucas L, Hillebrand MJX, Rosing H, Schellens JHM, Beijnen JH. van Andel L, et al. Among authors: lu s. Invest New Drugs. 2017 Dec;35(6):751-765. doi: 10.1007/s10637-017-0451-2. Epub 2017 Mar 16. Invest New Drugs. 2017. PMID: 28303528 Free PMC article.
Effects of Rolapitant Administered Intravenously or Orally on the Pharmacokinetics of Digoxin (P-glycoprotein Substrate) and Sulfasalazine (Breast Cancer Resistance Protein Substrate) in Healthy Volunteers.
Wang X, Zhang ZY, Arora S, Hughes L, Wang J, Powers D, Christensen J, Lu S, Kansra V. Wang X, et al. Among authors: lu s. J Clin Pharmacol. 2018 Feb;58(2):202-211. doi: 10.1002/jcph.1005. Epub 2017 Sep 14. J Clin Pharmacol. 2018. PMID: 28906558 Clinical Trial.
Effects of rolapitant administered orally on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects.
Wang J, Zhang ZY, Lu S, Powers D, Kansra V, Wang X. Wang J, et al. Among authors: lu s. Support Care Cancer. 2019 Mar;27(3):819-827. doi: 10.1007/s00520-018-4331-x. Epub 2018 Aug 6. Support Care Cancer. 2019. PMID: 30084103 Free PMC article. Clinical Trial.
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