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Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress.
Wilmes A, Limonciel A, Aschauer L, Moenks K, Bielow C, Leonard MO, Hamon J, Carpi D, Ruzek S, Handler A, Schmal O, Herrgen K, Bellwon P, Burek C, Truisi GL, Hewitt P, Di Consiglio E, Testai E, Blaauboer BJ, Guillou C, Huber CG, Lukas A, Pfaller W, Mueller SO, Bois FY, Dekant W, Jennings P. Wilmes A, et al. J Proteomics. 2013 Feb 21;79:180-94. doi: 10.1016/j.jprot.2012.11.022. Epub 2012 Dec 10. J Proteomics. 2013. PMID: 23238060 Free article.
Nrf2 inducibility of aldo-keto reductases.
Wilmes A, Leonard MO, Jennings P. Wilmes A, et al. Toxicol Lett. 2013 Jul 31;221(1):39. doi: 10.1016/j.toxlet.2013.05.012. Epub 2013 Jun 1. Toxicol Lett. 2013. PMID: 23732362 No abstract available.
Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics.
Wilmes A, Bielow C, Ranninger C, Bellwon P, Aschauer L, Limonciel A, Chassaigne H, Kristl T, Aiche S, Huber CG, Guillou C, Hewitt P, Leonard MO, Dekant W, Bois F, Jennings P. Wilmes A, et al. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27. doi: 10.1016/j.tiv.2014.10.006. Epub 2014 Oct 23. Toxicol In Vitro. 2015. PMID: 25450742
Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing.
Limonciel A, Moenks K, Stanzel S, Truisi GL, Parmentier C, Aschauer L, Wilmes A, Richert L, Hewitt P, Mueller SO, Lukas A, Kopp-Schneider A, Leonard MO, Jennings P. Limonciel A, et al. Among authors: wilmes a. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18. doi: 10.1016/j.tiv.2014.12.011. Epub 2015 Jan 13. Toxicol In Vitro. 2015. PMID: 25596134
Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline.
Ranninger C, Rurik M, Limonciel A, Ruzek S, Reischl R, Wilmes A, Jennings P, Hewitt P, Dekant W, Kohlbacher O, Huber CG. Ranninger C, et al. Among authors: wilmes a. J Biol Chem. 2015 Jul 31;290(31):19121-32. doi: 10.1074/jbc.M115.644146. Epub 2015 Jun 8. J Biol Chem. 2015. PMID: 26055719 Free PMC article.
60 results