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Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety.
Koizumi Y, Tanaka Y, Matsumura T, Kadoh Y, Miyoshi H, Hongu M, Takedomi K, Kotera J, Sasaki T, Taniguchi H, Watanabe Y, Takakuwa M, Kojima K, Baba N, Nakamura I, Kawanishi E. Koizumi Y, et al. Among authors: kojima k. Bioorg Med Chem. 2019 Aug 1;27(15):3440-3450. doi: 10.1016/j.bmc.2019.06.021. Epub 2019 Jun 19. Bioorg Med Chem. 2019. PMID: 31235264
Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor.
Kadoh Y, Miyoshi H, Matsumura T, Tanaka Y, Hongu M, Kimura M, Takedomi K, Omori K, Kotera J, Sasaki T, Kobayashi T, Taniguchi H, Watanabe Y, Kojima K, Sakamoto T, Himiyama T, Kawanishi E. Kadoh Y, et al. Among authors: kojima k. Chem Pharm Bull (Tokyo). 2018;66(3):243-250. doi: 10.1248/cpb.c17-00783. Chem Pharm Bull (Tokyo). 2018. PMID: 29491258 Free article.
Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism.
Miyazaki H, Ikeda Y, Sakurai O, Miyake T, Tsubota R, Okabe J, Kuroda M, Hisada Y, Yanagida T, Yoneda H, Tsukumo Y, Tokunaga S, Kawata T, Ohashi R, Fukuda H, Kojima K, Kannami A, Kifuji T, Sato N, Idei A, Iguchi T, Sakairi T, Moritani Y. Miyazaki H, et al. Among authors: kojima k. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2055-2060. doi: 10.1016/j.bmcl.2018.04.055. Epub 2018 Apr 24. Bioorg Med Chem Lett. 2018. PMID: 29724589 Free article.
Development of a mertansine-specific DNA aptamer and novel high-throughput sandwich enzyme-linked oligonucleotide assay for quantification and characterization of trastuzumab emtansine.
Yamada T, Furusho A, Kojima K, Sugiyama E, Mizuno H, Tsukakoshi K, Hayashi H, Yamano T, Hasebe T, Toyo'oka T, Ikebukuro K, Todoroki K. Yamada T, et al. Among authors: kojima k. Biosens Bioelectron. 2024 Dec 28;272:117108. doi: 10.1016/j.bios.2024.117108. Online ahead of print. Biosens Bioelectron. 2024. PMID: 39764977
Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases.
Suzuki N, Kojima K, Malvica S, Yamasaki K, Chikamatsu Y, Oe Y, Nagasawa T, Kondo E, Sanada S, Aiba S, Sato H, Miyazaki M, Ito S, Sato M, Tanaka T, Kinoshita K, Asano Y, Rosenberg AZ, Okamoto K, Shido K. Suzuki N, et al. Among authors: kojima k. Commun Med (Lond). 2025 Jan 5;5(1):3. doi: 10.1038/s43856-024-00708-3. Commun Med (Lond). 2025. PMID: 39757253 Free PMC article.
2,933 results