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Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety.
Koizumi Y, Tanaka Y, Matsumura T, Kadoh Y, Miyoshi H, Hongu M, Takedomi K, Kotera J, Sasaki T, Taniguchi H, Watanabe Y, Takakuwa M, Kojima K, Baba N, Nakamura I, Kawanishi E. Koizumi Y, et al. Among authors: matsumura t. Bioorg Med Chem. 2019 Aug 1;27(15):3440-3450. doi: 10.1016/j.bmc.2019.06.021. Epub 2019 Jun 19. Bioorg Med Chem. 2019. PMID: 31235264
Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor.
Kadoh Y, Miyoshi H, Matsumura T, Tanaka Y, Hongu M, Kimura M, Takedomi K, Omori K, Kotera J, Sasaki T, Kobayashi T, Taniguchi H, Watanabe Y, Kojima K, Sakamoto T, Himiyama T, Kawanishi E. Kadoh Y, et al. Among authors: matsumura t. Chem Pharm Bull (Tokyo). 2018;66(3):243-250. doi: 10.1248/cpb.c17-00783. Chem Pharm Bull (Tokyo). 2018. PMID: 29491258 Free article.
Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain.
Obokata N, Seki C, Hirata T, Maeda J, Ishii H, Nagai Y, Matsumura T, Takakuwa M, Fukuda H, Minamimoto T, Kawamura K, Zhang MR, Nakajima T, Saijo T, Higuchi M. Obokata N, et al. Among authors: matsumura t. Eur J Nucl Med Mol Imaging. 2021 Sep;48(10):3101-3112. doi: 10.1007/s00259-021-05269-4. Epub 2021 Mar 5. Eur J Nucl Med Mol Imaging. 2021. PMID: 33674894 Free PMC article.
Automated radiosynthesis of [11 C]MTP38-a phosphodiesterase 7 imaging tracer-using [11 C]hydrogen cyanide for clinical applications.
Kawamura K, Hashimoto H, Ohkubo T, Hanyu M, Ogawa M, Nengaki N, Arashi D, Kurihara Y, Fujishiro T, Togashi T, Sakai T, Muto M, Takei M, Ishii H, Saijo T, Matsumura T, Obokata N, Zhang MR. Kawamura K, et al. Among authors: matsumura t. J Labelled Comp Radiopharm. 2022 May 15;65(5):140-146. doi: 10.1002/jlcr.3965. Epub 2022 Feb 9. J Labelled Comp Radiopharm. 2022. PMID: 35122288
A Giant Aneurysm of Vieussens' Arterial Ring With Pulmonary Artery Fistula.
Nakata K, Moriyama S, Yoshinaga T, Ishimaru T, Doi H, Matsumura T, Fukui T. Nakata K, et al. Among authors: matsumura t. Ann Thorac Surg Short Rep. 2024 Jun 4;2(4):742-745. doi: 10.1016/j.atssr.2024.05.008. eCollection 2024 Dec. Ann Thorac Surg Short Rep. 2024. PMID: 39790610 Free PMC article.
Efficacy of tranilast in preventing exacerbating cardiac function and death from heart failure in muscular dystrophy patients with advanced-stage heart failure: a single-arm, open-label, multicenter study.
Matsumura T, Fukudome T, Motoyoshi Y, Nakamura A, Kuru S, Segawa K, Kitao R, Watanabe C, Tamura T, Takahashi T, Hashimoto H, Sekimizu M, Saito AM, Asakura M, Kimura K, Iwata Y. Matsumura T, et al. Orphanet J Rare Dis. 2025 Jan 9;20(1):13. doi: 10.1186/s13023-025-03538-1. Orphanet J Rare Dis. 2025. PMID: 39789553 Free article.
An unstable variant of GAP43 leads to neurodevelopmental deficiency.
Noda M, Matsumoto A, Ito H, Kagami M, Tajima T, Matsumura T, Yamagata T, Nagata KI. Noda M, et al. Among authors: matsumura t. Sci Rep. 2024 Dec 30;14(1):31911. doi: 10.1038/s41598-024-83445-w. Sci Rep. 2024. PMID: 39738362 Free PMC article.
2,203 results