Malik FI - Search Results

1

Fast skeletal muscle troponin activator CK-2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction.

Cheng AJ, Hwee DT, Kim LH, Durham N, Yang HT, Hinken AC, Kennedy AR, Terjung RL, Jasper JR, Malik FI, Westerblad H. Cheng AJ, et al. Among authors: malik fi. J Physiol. 2019 Sep;597(17):4615-4625. doi: 10.1113/JP278235. Epub 2019 Jul 17. J Physiol. 2019. PMID: 31246276 Free PMC article.

2

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases.

Russell AJ, Hartman JJ, Hinken AC, Muci AR, Kawas R, Driscoll L, Godinez G, Lee KH, Marquez D, Browne WF 4th, Chen MM, Clarke D, Collibee SE, Garard M, Hansen R, Jia Z, Lu PP, Rodriguez H, Saikali KG, Schaletzky J, Vijayakumar V, Albertus DL, Claflin DR, Morgans DJ, Morgan BP, Malik FI. Russell AJ, et al. Among authors: malik fi. Nat Med. 2012 Feb 19;18(3):452-5. doi: 10.1038/nm.2618. Nat Med. 2012. PMID: 22344294 Free PMC article.

3

Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency.

Lee EJ, De Winter JM, Buck D, Jasper JR, Malik FI, Labeit S, Ottenheijm CA, Granzier H. Lee EJ, et al. Among authors: malik fi. PLoS One. 2013;8(2):e55861. doi: 10.1371/journal.pone.0055861. Epub 2013 Feb 20. PLoS One. 2013. PMID: 23437068 Free PMC article.

4

Fast skeletal muscle troponin activator in the dy2J muscular dystrophy model.

Miciak JJ, Warsing LC, Tibbs ME, Jasper JR, Jampel SB, Malik FI, Tankersley C, Wagner KR. Miciak JJ, et al. Among authors: malik fi. Muscle Nerve. 2013 Aug;48(2):279-85. doi: 10.1002/mus.23848. Epub 2013 Jun 29. Muscle Nerve. 2013. PMID: 23512724

5

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations.

de Winter JM, Buck D, Hidalgo C, Jasper JR, Malik FI, Clarke NF, Stienen GJ, Lawlor MW, Beggs AH, Ottenheijm CA, Granzier H. de Winter JM, et al. Among authors: malik fi. J Med Genet. 2013 Jun;50(6):383-92. doi: 10.1136/jmedgenet-2012-101470. Epub 2013 Apr 9. J Med Genet. 2013. PMID: 23572184 Free PMC article.

6

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.

Ottenheijm CA, Buck D, de Winter JM, Ferrara C, Piroddi N, Tesi C, Jasper JR, Malik FI, Meng H, Stienen GJ, Beggs AH, Labeit S, Poggesi C, Lawlor MW, Granzier H. Ottenheijm CA, et al. Among authors: malik fi. Brain. 2013 Jun;136(Pt 6):1718-31. doi: 10.1093/brain/awt113. Epub 2013 May 28. Brain. 2013. PMID: 23715096 Free PMC article.

7

Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model.

Hwee DT, Kennedy A, Ryans J, Russell AJ, Jia Z, Hinken AC, Morgans DJ, Malik FI, Jasper JR. Hwee DT, et al. Among authors: malik fi. PLoS One. 2014 May 7;9(5):e96921. doi: 10.1371/journal.pone.0096921. eCollection 2014. PLoS One. 2014. PMID: 24805850 Free PMC article.

8

The small-molecule fast skeletal troponin activator, CK-2127107, improves exercise tolerance in a rat model of heart failure.

Hwee DT, Kennedy AR, Hartman JJ, Ryans J, Durham N, Malik FI, Jasper JR. Hwee DT, et al. Among authors: malik fi. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68. doi: 10.1124/jpet.114.222224. Epub 2015 Feb 12. J Pharmacol Exp Ther. 2015. PMID: 25678535

9

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension.

Manders E, Bonta PI, Kloek JJ, Symersky P, Bogaard HJ, Hooijman PE, Jasper JR, Malik FI, Stienen GJ, Vonk-Noordegraaf A, de Man FS, Ottenheijm CA. Manders E, et al. Among authors: malik fi. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L20-8. doi: 10.1152/ajplung.00113.2016. Epub 2016 May 17. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27190061 Free PMC article.

10

The Ca²⁺ sensitizer CK-2066260 increases myofibrillar Ca²⁺ sensitivity and submaximal force selectively in fast skeletal muscle.

Hwee DT, Cheng AJ, Hartman JJ, Hinken AC, Lee K, Durham N, Russell AJ, Malik FI, Westerblad H, Jasper JR. Hwee DT, et al. Among authors: malik fi. J Physiol. 2017 Mar 1;595(5):1657-1670. doi: 10.1113/JP273248. Epub 2017 Jan 24. J Physiol. 2017. PMID: 27869319 Free PMC article.

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