Mutlib A - Search Results

1

Evaluation of absorption, distribution, metabolism, and excretion of [¹⁴C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors.

Liao M, Watkins S, Nash E, Isaacson J, Etter J, Beltman J, Fan R, Shen L, Mutlib A, Kemeny V, Pápai Z, van Tilburg P, Xiao JJ. Liao M, et al. Among authors: mutlib a. Invest New Drugs. 2020 Jun;38(3):765-775. doi: 10.1007/s10637-019-00815-2. Epub 2019 Jun 27. Invest New Drugs. 2020. PMID: 31250355 Free PMC article. Clinical Trial.

2

Pharmacokinetics and Comprehensive Analysis of the Tissue Distribution of Eravacycline in Rabbits.

Petraitis V, Petraitiene R, Maung BBW, Khan F, Alisauskaite I, Olesky M, Newman J, Mutlib A, Niu X, Satlin M, Singh RS, Derendorf H, Walsh TJ. Petraitis V, et al. Among authors: mutlib a. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e00275-18. doi: 10.1128/AAC.00275-18. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 29941646 Free PMC article.

3

The pharmacokinetics and tissue distribution of gomphoside in Wistar rats.

Mutlib AE, Watson TR. Mutlib AE, et al. Eur J Drug Metab Pharmacokinet. 1989 Apr-Jun;14(2):117-25. doi: 10.1007/BF03190851. Eur J Drug Metab Pharmacokinet. 1989. PMID: 2591416

4

Alternate strategies to obtain mass balance without the use of radiolabeled compounds: application of quantitative fluorine (19F) nuclear magnetic resonance (NMR) spectroscopy in metabolism studies.

Mutlib A, Espina R, Atherton J, Wang J, Talaat R, Scatina J, Chandrasekaran A. Mutlib A, et al. Chem Res Toxicol. 2012 Mar 19;25(3):572-83. doi: 10.1021/tx2005629. Epub 2012 Feb 10. Chem Res Toxicol. 2012. PMID: 22292524

5

In vitro metabolism of the cardiotonic steroids gomphogenin and calactin.

Mutlib AE, Cheung HT, Watson TR. Mutlib AE, et al. J Steroid Biochem. 1988 Jan;29(1):135-43. doi: 10.1016/0022-4731(88)90387-1. J Steroid Biochem. 1988. PMID: 3347047

6

In vivo and in vitro metabolism of gomphoside, a cardiotonic steroid with doubly-linked sugar.

Mutlib AE, Cheung HT, Watson TR. Mutlib AE, et al. J Steroid Biochem. 1987 Jul;28(1):65-75. doi: 10.1016/0022-4731(87)90126-9. J Steroid Biochem. 1987. PMID: 3613576

7

Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy.

Walker GS, Atherton J, Bauman J, Kohl C, Lam W, Reily M, Lou Z, Mutlib A. Walker GS, et al. Among authors: mutlib a. Chem Res Toxicol. 2007 Jun;20(6):876-86. doi: 10.1021/tx600297u. Epub 2007 May 31. Chem Res Toxicol. 2007. PMID: 17536843

8

Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing.

Espina R, Yu L, Wang J, Tong Z, Vashishtha S, Talaat R, Scatina J, Mutlib A. Espina R, et al. Among authors: mutlib a. Chem Res Toxicol. 2009 Feb;22(2):299-310. doi: 10.1021/tx800251p. Chem Res Toxicol. 2009. PMID: 18980340

9

Application of quantitative NMR in pharmacological evaluation of biologically generated metabolites: implications in drug discovery.

Mutlib A, Espina R, Vishwanathan K, Babalola K, Chen Z, Dehnhardt C, Venkatesan A, Mansour T, Chaudhary I, Talaat R, Scatina J. Mutlib A, et al. Drug Metab Dispos. 2011 Jan;39(1):106-16. doi: 10.1124/dmd.110.032490. Epub 2010 Oct 15. Drug Metab Dispos. 2011. PMID: 20952552

10

Bioactivation of benzylamine to reactive intermediates in rodents: formation of glutathione, glutamate, and peptide conjugates.

Mutlib AE, Dickenson P, Chen SY, Espina RJ, Daniels JS, Gan LS. Mutlib AE, et al. Chem Res Toxicol. 2002 Sep;15(9):1190-207. doi: 10.1021/tx020063q. Chem Res Toxicol. 2002. PMID: 12230413

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