Tozawa R - Search Results

1

Phenotypic Drug Screening for Dysferlinopathy Using Patient-Derived Induced Pluripotent Stem Cells.

Kokubu Y, Nagino T, Sasa K, Oikawa T, Miyake K, Kume A, Fukuda M, Fuse H, Tozawa R, Sakurai H. Kokubu Y, et al. Among authors: tozawa r. Stem Cells Transl Med. 2019 Oct;8(10):1017-1029. doi: 10.1002/sctm.18-0280. Epub 2019 Jun 28. Stem Cells Transl Med. 2019. PMID: 31250983 Free PMC article.

2

Identification of 2,6-Disubstituted 3H-Imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived Induced Pluripotent Stem Cells.

Takada H, Kaieda A, Tawada M, Nagino T, Sasa K, Oikawa T, Oki A, Sameshima T, Miyamoto K, Miyamoto M, Kokubu Y, Tozawa R, Sakurai H, Saito B. Takada H, et al. Among authors: tozawa r. J Med Chem. 2019 Oct 24;62(20):9175-9187. doi: 10.1021/acs.jmedchem.9b01100. Epub 2019 Oct 7. J Med Chem. 2019. PMID: 31550153

3

Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice.

Moritoh Y, Oka M, Yasuhara Y, Hozumi H, Iwachidow K, Fuse H, Tozawa R. Moritoh Y, et al. Among authors: tozawa r. Sci Rep. 2016 Aug 31;6:32072. doi: 10.1038/srep32072. Sci Rep. 2016. PMID: 27577108 Free PMC article.

4

Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice.

Taniyama Y, Fuse H, Satomi T, Tozawa R, Yasuhara Y, Shimakawa K, Shibata S, Hattori M, Nakata M, Taketomi S. Taniyama Y, et al. Among authors: tozawa r. Biochem Biophys Res Commun. 2005 Apr 29;330(1):104-10. doi: 10.1016/j.bbrc.2005.02.126. Biochem Biophys Res Commun. 2005. PMID: 15781238

5

Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.

Nishimoto T, Ishikawa E, Anayama H, Hamajyo H, Nagai H, Hirakata M, Tozawa R. Nishimoto T, et al. Among authors: tozawa r. Toxicol Appl Pharmacol. 2007 Aug 15;223(1):39-45. doi: 10.1016/j.taap.2007.05.005. Epub 2007 May 24. Toxicol Appl Pharmacol. 2007. PMID: 17599378

Previously we showed that T-91485, an active metabolite of the squalene synthase inhibitor lapaquistat acetate (lapaquistat: a previous name is TAK-475), attenuated statin-induced cytotoxicity in human skeletal muscle cells [Nishimoto, T., Tozawa, R., Amano, Y., Wad …

Previously we showed that T-91485, an active metabolite of the squalene synthase inhibitor lapaquistat acetate (lapaquistat: a previous name …

6

Ngly1 -/- rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems.

Asahina M, Fujinawa R, Nakamura S, Yokoyama K, Tozawa R, Suzuki T. Asahina M, et al. Among authors: tozawa r. Hum Mol Genet. 2020 Jun 27;29(10):1635-1647. doi: 10.1093/hmg/ddaa059. Hum Mol Genet. 2020. PMID: 32259258 Free PMC article.

7

Pharmacological evaluation of pioglitazone and candesartan cilexetil in a novel mouse model of non-alcoholic steatohepatitis, modified choline-deficient, amino acid-defined diet fed low-density lipoprotein receptor knockout mice.

Tsuchiya S, Amano Y, Isono O, Imai M, Shimizu F, Asada M, Imai S, Harada A, Yasuhara Y, Tozawa R, Nagabukuro H. Tsuchiya S, et al. Among authors: tozawa r. Hepatol Res. 2017 May;47(6):584-592. doi: 10.1111/hepr.12773. Epub 2016 Aug 17. Hepatol Res. 2017. PMID: 27421062

8

Osborne-Mendel rats simultaneously develop cardiac and renal dysfunction, left atrial thrombosis, peripheral artery occlusion, and ascending aortic dissection.

Asahina M, Matsumoto H, Yasuhara Y, Suzuki N, Takami R, Takeyama M, Tozawa R. Asahina M, et al. Among authors: tozawa r. Biochem Biophys Res Commun. 2017 Apr 1;485(2):550-555. doi: 10.1016/j.bbrc.2017.01.049. Epub 2017 Jan 12. Biochem Biophys Res Commun. 2017. PMID: 28088517 Free article.

9

Hypercholesterolemia and atherosclerosis in low density lipoprotein receptor mutant rats.

Asahina M, Mashimo T, Takeyama M, Tozawa R, Hashimoto T, Takizawa A, Ueda M, Aoto T, Kuramoto T, Serikawa T. Asahina M, et al. Among authors: tozawa r. Biochem Biophys Res Commun. 2012 Feb 17;418(3):553-8. doi: 10.1016/j.bbrc.2012.01.067. Epub 2012 Jan 24. Biochem Biophys Res Commun. 2012. PMID: 22293196

10

Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation.

Hirakata M, Tozawa R, Imura Y, Sugiyama Y. Hirakata M, et al. Among authors: tozawa r. Biochem Biophys Res Commun. 2004 Oct 22;323(3):782-8. doi: 10.1016/j.bbrc.2004.08.151. Biochem Biophys Res Commun. 2004. PMID: 15381068

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