Blundell TL - Search Results

1

Development of Inhibitors against Mycobacterium abscessus tRNA (m¹G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.

Whitehouse AJ, Thomas SE, Brown KP, Fanourakis A, Chan DS, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG. Whitehouse AJ, et al. Among authors: blundell tl. J Med Chem. 2019 Aug 8;62(15):7210-7232. doi: 10.1021/acs.jmedchem.9b00809. Epub 2019 Jul 19. J Med Chem. 2019. PMID: 31282680 Free PMC article.

2

Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing.

Albert A, Dhanaraj V, Genschel U, Khan G, Ramjee MK, Pulido R, Sibanda BL, von Delft F, Witty M, Blundell TL, Smith AG, Abell C. Albert A, et al. Among authors: blundell tl. Nat Struct Biol. 1998 Apr;5(4):289-93. doi: 10.1038/nsb0498-289. Nat Struct Biol. 1998. PMID: 9546220

3

The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily.

von Delft F, Lewendon A, Dhanaraj V, Blundell TL, Abell C, Smith AG. von Delft F, et al. Among authors: blundell tl. Structure. 2001 May 9;9(5):439-50. doi: 10.1016/s0969-2126(01)00604-9. Structure. 2001. PMID: 11377204 Free article.

4

Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism.

Matak-Vinković D, Vinković M, Saldanha SA, Ashurst JL, von Delft F, Inoue T, Miguel RN, Smith AG, Blundell TL, Abell C. Matak-Vinković D, et al. Among authors: blundell tl. Biochemistry. 2001 Dec 4;40(48):14493-500. doi: 10.1021/bi011020w. Biochemistry. 2001. PMID: 11724562

5

High-throughput crystallography for lead discovery in drug design.

Blundell TL, Jhoti H, Abell C. Blundell TL, et al. Nat Rev Drug Discov. 2002 Jan;1(1):45-54. doi: 10.1038/nrd706. Nat Rev Drug Discov. 2002. PMID: 12119609 Review.

6

Structural insights into the evolution of the pantothenate-biosynthesis pathway.

Lobley CM, Schmitzberger F, Kilkenny ML, Whitney H, Ottenhof HH, Chakauya E, Webb ME, Birch LM, Tuck KL, Abell C, Smith AG, Blundell TL. Lobley CM, et al. Among authors: blundell tl. Biochem Soc Trans. 2003 Jun;31(Pt 3):563-71. doi: 10.1042/bst0310563. Biochem Soc Trans. 2003. PMID: 12773157

7

Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms that it is a member of the (betaalpha)8 phosphoenolpyruvate/pyruvate superfamily.

Schmitzberger F, Smith AG, Abell C, Blundell TL. Schmitzberger F, et al. Among authors: blundell tl. J Bacteriol. 2003 Jul;185(14):4163-71. doi: 10.1128/JB.185.14.4163-4171.2003. J Bacteriol. 2003. PMID: 12837791 Free PMC article.

8

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites.

von Delft F, Inoue T, Saldanha SA, Ottenhof HH, Schmitzberger F, Birch LM, Dhanaraj V, Witty M, Smith AG, Blundell TL, Abell C. von Delft F, et al. Among authors: blundell tl. Structure. 2003 Aug;11(8):985-96. doi: 10.1016/s0969-2126(03)00158-8. Structure. 2003. PMID: 12906829 Free article.

9

Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase.

Schmitzberger F, Kilkenny ML, Lobley CM, Webb ME, Vinkovic M, Matak-Vinkovic D, Witty M, Chirgadze DY, Smith AG, Abell C, Blundell TL. Schmitzberger F, et al. Among authors: blundell tl. EMBO J. 2003 Dec 1;22(23):6193-204. doi: 10.1093/emboj/cdg575. EMBO J. 2003. PMID: 14633979 Free PMC article.

10

The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound.

Lobley CM, Ciulli A, Whitney HM, Williams G, Smith AG, Abell C, Blundell TL. Lobley CM, et al. Among authors: blundell tl. Biochemistry. 2005 Jun 28;44(25):8930-9. doi: 10.1021/bi0502036. Biochemistry. 2005. PMID: 15966718

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