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Page 1
The impact of dietary fermentable carbohydrates on a postinflammatory model of irritable bowel syndrome.
Tuck CJ, Caminero A, Jiménez Vargas NN, Soltys CL, Jaramillo Polanco JO, Lopez Lopez CD, Constante M, Lourenssen SR, Verdu EF, Muir JG, Lomax AE, Reed DE, Vanner SJ. Tuck CJ, et al. Among authors: jimenez vargas nn. Neurogastroenterol Motil. 2019 Oct;31(10):e13675. doi: 10.1111/nmo.13675. Epub 2019 Jul 9. Neurogastroenterol Motil. 2019. PMID: 31290223
Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW. Zhao P, et al. Among authors: jimenez vargas nn. J Biol Chem. 2015 May 29;290(22):13875-87. doi: 10.1074/jbc.M115.642736. Epub 2015 Apr 15. J Biol Chem. 2015. PMID: 25878251 Free PMC article.
Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.
Jensen DD, Zhao P, Jimenez-Vargas NN, Lieu T, Gerges M, Yeatman HR, Canals M, Vanner SJ, Poole DP, Bunnett NW. Jensen DD, et al. Among authors: jimenez vargas nn. J Biol Chem. 2016 May 20;291(21):11285-99. doi: 10.1074/jbc.M115.710681. Epub 2016 Mar 30. J Biol Chem. 2016. PMID: 27030010 Free PMC article.
Co-expression of μ and δ opioid receptors by mouse colonic nociceptors.
Guerrero-Alba R, Valdez-Morales EE, Jiménez-Vargas NN, Bron R, Poole D, Reed D, Castro J, Campaniello M, Hughes PA, Brierley SM, Bunnett N, Lomax AE, Vanner S. Guerrero-Alba R, et al. Among authors: jimenez vargas nn. Br J Pharmacol. 2018 Jul;175(13):2622-2634. doi: 10.1111/bph.14222. Epub 2018 May 22. Br J Pharmacol. 2018. PMID: 29579315 Free PMC article.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW. Jimenez-Vargas NN, et al. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012612 Free PMC article.
Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.
Zhao P, Pattison LA, Jensen DD, Jimenez-Vargas NN, Latorre R, Lieu T, Jaramillo JO, Lopez-Lopez C, Poole DP, Vanner SJ, Schmidt BL, Bunnett NW. Zhao P, et al. Among authors: jimenez vargas nn. J Biol Chem. 2019 Jul 5;294(27):10649-10662. doi: 10.1074/jbc.RA118.006935. Epub 2019 May 29. J Biol Chem. 2019. PMID: 31142616 Free PMC article.
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.
Jimenez-Vargas NN, Gong J, Wisdom MJ, Jensen DD, Latorre R, Hegron A, Teng S, DiCello JJ, Rajasekhar P, Veldhuis NA, Carbone SE, Yu Y, Lopez-Lopez C, Jaramillo-Polanco J, Canals M, Reed DE, Lomax AE, Schmidt BL, Leong KW, Vanner SJ, Halls ML, Bunnett NW, Poole DP. Jimenez-Vargas NN, et al. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15281-15292. doi: 10.1073/pnas.2000500117. Epub 2020 Jun 16. Proc Natl Acad Sci U S A. 2020. PMID: 32546520 Free PMC article.
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
Tu NH, Jensen DD, Anderson BM, Chen E, Jimenez-Vargas NN, Scheff NN, Inoue K, Tran HD, Dolan JC, Meek TA, Hollenberg MD, Liu CZ, Vanner SJ, Janal MN, Bunnett NW, Edgington-Mitchell LE, Schmidt BL. Tu NH, et al. Among authors: jimenez vargas nn. J Neurosci. 2021 Jan 6;41(1):193-210. doi: 10.1523/JNEUROSCI.1211-20.2020. Epub 2020 Nov 10. J Neurosci. 2021. PMID: 33172978 Free PMC article.
Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects.
Jiménez-Vargas NN, Yu Y, Jensen DD, Bok DD, Wisdom M, Latorre R, Lopez C, Jaramillo-Polanco JO, Degro C, Guzman-Rodriguez M, Tsang Q, Snow Z, Schmidt BL, Reed DE, Lomax AE, Margolis KG, Stein C, Bunnett NW, Vanner SJ. Jiménez-Vargas NN, et al. Gut. 2022 Apr;71(4):695-704. doi: 10.1136/gutjnl-2021-324070. Epub 2021 Mar 30. Gut. 2022. PMID: 33785555 Free PMC article.
20 results