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Page 1
Pharmacokinetic and Pharmacodynamic Effects of a γ-Secretase Modulator, PF-06648671, on CSF Amyloid-β Peptides in Randomized Phase I Studies.
Ahn JE, Carrieri C, Dela Cruz F, Fullerton T, Hajos-Korcsok E, He P, Kantaridis C, Leurent C, Liu R, Mancuso J, Mendes da Costa L, Qiu R. Ahn JE, et al. Among authors: leurent c. Clin Pharmacol Ther. 2020 Jan;107(1):211-220. doi: 10.1002/cpt.1570. Epub 2019 Sep 11. Clin Pharmacol Ther. 2020. PMID: 31314925 Free PMC article.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects.
Qiu R, Ahn JE, Alexander R, Brodney MA, He P, Leurent C, Mancuso J, Margolin RA, Tankisheva E, Chen D. Qiu R, et al. Among authors: leurent c. J Alzheimers Dis. 2019;71(2):581-595. doi: 10.3233/JAD-190228. J Alzheimers Dis. 2019. PMID: 31424395 Free PMC article. Clinical Trial.
Immunotherapy with ponezumab for probable cerebral amyloid angiopathy.
Leurent C, Goodman JA, Zhang Y, He P, Polimeni JR, Gurol ME, Lindsay M, Frattura L, Sohur US, Viswanathan A, Bednar MM, Smith EE; Ponezumab Trial Study Group; Greenberg SM. Leurent C, et al. Ann Clin Transl Neurol. 2019 Mar 18;6(4):795-806. doi: 10.1002/acn3.761. eCollection 2019 Apr. Ann Clin Transl Neurol. 2019. PMID: 31020004 Free PMC article.
Desvenlafaxine and weight change in major depressive disorder.
Tourian KA, Leurent C, Graepel J, Ninan PT. Tourian KA, et al. Among authors: leurent c. Prim Care Companion J Clin Psychiatry. 2010;12(1):PCC.08m00746. doi: 10.4088/PCC.08m00746blu. Prim Care Companion J Clin Psychiatry. 2010. PMID: 20582292 Free PMC article.
Mapping key functional sites within yeast TFIID.
Leurent C, Sanders SL, Demény MA, Garbett KA, Ruhlmann C, Weil PA, Tora L, Schultz P. Leurent C, et al. EMBO J. 2004 Feb 25;23(4):719-27. doi: 10.1038/sj.emboj.7600111. Epub 2004 Feb 12. EMBO J. 2004. PMID: 14765106 Free PMC article.
Mapping histone fold TAFs within yeast TFIID.
Leurent C, Sanders S, Ruhlmann C, Mallouh V, Weil PA, Kirschner DB, Tora L, Schultz P. Leurent C, et al. EMBO J. 2002 Jul 1;21(13):3424-33. doi: 10.1093/emboj/cdf342. EMBO J. 2002. PMID: 12093743 Free PMC article.