Lo CH - Search Results

1

Noncompetitive inhibitors of TNFR1 probe conformational activation states.

Lo CH, Schaaf TM, Grant BD, Lim CK, Bawaskar P, Aldrich CC, Thomas DD, Sachs JN. Lo CH, et al. Sci Signal. 2019 Jul 30;12(592):eaav5637. doi: 10.1126/scisignal.aav5637. Sci Signal. 2019. PMID: 31363069 Free PMC article.

2

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors.

Lo CH, Vunnam N, Lewis AK, Chiu TL, Brummel BE, Schaaf TM, Grant BD, Bawaskar P, Thomas DD, Sachs JN. Lo CH, et al. SLAS Discov. 2017 Sep;22(8):950-961. doi: 10.1177/2472555217706478. Epub 2017 May 22. SLAS Discov. 2017. PMID: 28530838 Free PMC article.

3

Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor-Receptor Interactions.

Vunnam N, Lo CH, Grant BD, Thomas DD, Sachs JN. Vunnam N, et al. Among authors: lo ch. J Mol Biol. 2017 Sep 15;429(19):2943-2953. doi: 10.1016/j.jmb.2017.08.009. Epub 2017 Aug 20. J Mol Biol. 2017. PMID: 28834692

4

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies.

Lo CH, Lim CK, Ding Z, Wickramasinghe SP, Braun AR, Ashe KH, Rhoades E, Thomas DD, Sachs JN. Lo CH, et al. Alzheimers Dement. 2019 Nov;15(11):1489-1502. doi: 10.1016/j.jalz.2019.06.4954. Epub 2019 Oct 22. Alzheimers Dement. 2019. PMID: 31653529 Free PMC article.

5

Conformational states of TNFR1 as a molecular switch for receptor function.

Lo CH, Huber EC, Sachs JN. Lo CH, et al. Protein Sci. 2020 Jun;29(6):1401-1415. doi: 10.1002/pro.3829. Epub 2020 Jan 31. Protein Sci. 2020. PMID: 31960514 Free PMC article.

6

Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells.

Lo CH, Pandey NK, Lim CK, Ding Z, Tao M, Thomas DD, Langen R, Sachs JN. Lo CH, et al. ACS Chem Neurosci. 2020 Aug 5;11(15):2286-2295. doi: 10.1021/acschemneuro.0c00226. Epub 2020 Jul 7. ACS Chem Neurosci. 2020. PMID: 32568514

7

Fluorescence-Based TNFR1 Biosensor for Monitoring Receptor Structural and Conformational Dynamics and Discovery of Small Molecule Modulators.

Lo CH, Schaaf TM, Thomas DD, Sachs JN. Lo CH, et al. Methods Mol Biol. 2021;2248:121-137. doi: 10.1007/978-1-0716-1130-2_9. Methods Mol Biol. 2021. PMID: 33185872

8

The role of wild-type tau in Alzheimer's disease and related tauopathies.

Lo CH, Sachs JN. Lo CH, et al. J Life Sci (Westlake Village). 2020 Dec;2(4):1-17. doi: 10.36069/jols/20201201. J Life Sci (Westlake Village). 2020. PMID: 33665646 Free PMC article.

9

Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors.

Braun AR, Liao EE, Horvath M, Kalra P, Acosta K, Young MC, Kochen NN, Lo CH, Brown R, Evans MD, Pomerantz WCK, Rhoades E, Luk K, Cornea RL, Thomas DD, Sachs JN. Braun AR, et al. Among authors: lo ch. NPJ Parkinsons Dis. 2021 Jun 28;7(1):52. doi: 10.1038/s41531-021-00195-6. NPJ Parkinsons Dis. 2021. PMID: 34183676 Free PMC article.

10

Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease.

Vunnam N, Hansen S, Williams DC, Been MO, Lo CH, Pandey AK, Paulson CN, Rohde JA, Thomas DD, Sachs JN, Wood DK. Vunnam N, et al. Among authors: lo ch. Biomacromolecules. 2022 Sep 12;23(9):3822-3830. doi: 10.1021/acs.biomac.2c00671. Epub 2022 Aug 9. Biomacromolecules. 2022. PMID: 35944154 Free PMC article.

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