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Evolution of l-DOPA 4,5-dioxygenase activity allows for recurrent specialisation to betalain pigmentation in Caryophyllales.
Sheehan H, Feng T, Walker-Hale N, Lopez-Nieves S, Pucker B, Guo R, Yim WC, Badgami R, Timoneda A, Zhao L, Tiley H, Copetti D, Sanderson MJ, Cushman JC, Moore MJ, Smith SA, Brockington SF. Sheehan H, et al. New Phytol. 2020 Aug;227(3):914-929. doi: 10.1111/nph.16089. Epub 2019 Sep 29. New Phytol. 2020. PMID: 31369159 Free PMC article.
The evolution of betalain biosynthesis in Caryophyllales.
Timoneda A, Feng T, Sheehan H, Walker-Hale N, Pucker B, Lopez-Nieves S, Guo R, Brockington S. Timoneda A, et al. Among authors: sheehan h. New Phytol. 2019 Oct;224(1):71-85. doi: 10.1111/nph.15980. Epub 2019 Jul 19. New Phytol. 2019. PMID: 31172524 Free article. Review.
Are seven amino acid substitutions sufficient to explain the evolution of high l-DOPA 4,5-dioxygenase activity leading to betalain pigmentation? Revisiting the gain-of-function mutants of Bean et al. (2018).
Guerrero-Rubio MA, Walker-Hale N, Guo R, Sheehan H, Timoneda A, Gandia-Herrero F, Brockington SF. Guerrero-Rubio MA, et al. Among authors: sheehan h. New Phytol. 2023 Sep;239(6):2265-2276. doi: 10.1111/nph.18981. Epub 2023 May 27. New Phytol. 2023. PMID: 37243529 Free article.
Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design.
Hryczanek RP, Hackett AS, Rowland P, Chung CW, Convery MA, Holmes DS, Hutchinson JP, Kitchen S, Korczynska J, Law RP, Lea JD, Liddle J, Lonsdale R, Neu M, Nickels L, Phillipou A, Rowedder JE, Schneck JL, Scott-Stevens P, Sheehan H, Tayler CL, Temponeras I, Tinworth CP, Walker AL, Wojno-Picon J, Young RJ, Lindsay DM, Stratikos E. Hryczanek RP, et al. Among authors: sheehan h. ACS Med Chem Lett. 2024 Nov 6;15(12):2107-2114. doi: 10.1021/acsmedchemlett.4c00401. eCollection 2024 Dec 12. ACS Med Chem Lett. 2024. PMID: 39691536 Free PMC article.
An eight-founder wheat MAGIC population allows fine-mapping of flowering time loci and provides novel insights into the genetic control of flowering time.
Fourquet L, Barber T, Campos-Mantello C, Howell P, Orman-Ligeza B, Percival-Alwyn L, Rose GA, Sheehan H, Wright TIC, Longin F, Würschum T, Novoselovic D, Greenland AJ, Mackay IJ, Cockram J, Bentley AR. Fourquet L, et al. Among authors: sheehan h. Theor Appl Genet. 2024 Nov 22;137(12):277. doi: 10.1007/s00122-024-04787-7. Theor Appl Genet. 2024. PMID: 39576319 Free PMC article.
138 results