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Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
Pinkerton AB, Peddibhotla S, Yamamoto F, Slosky LM, Bai Y, Maloney P, Hershberger P, Hedrick MP, Falter B, Ardecky RJ, Smith LH, Chung TDY, Jackson MR, Caron MG, Barak LS. Pinkerton AB, et al. Among authors: bai y. J Med Chem. 2019 Sep 12;62(17):8357-8363. doi: 10.1021/acs.jmedchem.9b00340. Epub 2019 Aug 20. J Med Chem. 2019. PMID: 31390201 Free PMC article.
Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.
Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME. Zhao P, et al. Among authors: bai y. Mol Pharmacol. 2010 Oct;78(4):560-8. doi: 10.1124/mol.110.066746. Epub 2010 Jul 22. Mol Pharmacol. 2010. PMID: 20826425 Free PMC article.
Triphenylmethane dye activation of beta-arrestin.
Barak LS, Bai Y, Snyder JC, Wang J, Chen W, Caron MG. Barak LS, et al. Among authors: bai y. Biochemistry. 2013 Aug 13;52(32):5403-14. doi: 10.1021/bi400217r. Epub 2013 Aug 1. Biochemistry. 2013. PMID: 23865508 Free PMC article.
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
Kotsikorou E, Sharir H, Shore DM, Hurst DP, Lynch DL, Madrigal KE, Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak LS, Croatt MP, Abood ME, Reggio PH. Kotsikorou E, et al. Among authors: bai y. Biochemistry. 2013 Dec 31;52(52):9456-69. doi: 10.1021/bi4008885. Epub 2013 Dec 17. Biochemistry. 2013. PMID: 24274581 Free PMC article.
G Protein and β-arrestin signaling bias at the ghrelin receptor.
Evron T, Peterson SM, Urs NM, Bai Y, Rochelle LK, Caron MG, Barak LS. Evron T, et al. Among authors: bai y. J Biol Chem. 2014 Nov 28;289(48):33442-55. doi: 10.1074/jbc.M114.581397. Epub 2014 Sep 26. J Biol Chem. 2014. PMID: 25261469 Free PMC article.
A rapid and affordable screening platform for membrane protein trafficking.
Snyder JC, Pack TF, Rochelle LK, Chakraborty SK, Zhang M, Eaton AW, Bai Y, Ernst LA, Barak LS, Waggoner AS, Caron MG. Snyder JC, et al. Among authors: bai y. BMC Biol. 2015 Dec 17;13:107. doi: 10.1186/s12915-015-0216-3. BMC Biol. 2015. PMID: 26678094 Free PMC article.
ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.
Barak LS, Bai Y, Peterson S, Evron T, Urs NM, Peddibhotla S, Hedrick MP, Hershberger P, Maloney PR, Chung TD, Rodriguiz RM, Wetsel WC, Thomas JB, Hanson GR, Pinkerton AB, Caron MG. Barak LS, et al. Among authors: bai y. ACS Chem Biol. 2016 Jul 15;11(7):1880-90. doi: 10.1021/acschembio.6b00291. Epub 2016 May 5. ACS Chem Biol. 2016. PMID: 27119457 Free PMC article.
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