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Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma.
Nakagawa M, Nakatani F, Matsunaga H, Seki T, Endo M, Ogawara Y, Machida Y, Katsumoto T, Yamagata K, Hattori A, Fujita S, Aikawa Y, Ishikawa T, Soga T, Kawai A, Chuman H, Yokoyama N, Fukushima S, Yahiro K, Kimura A, Shimada E, Hirose T, Fujiwara T, Setsu N, Matsumoto Y, Iwamoto Y, Nakashima Y, Kitabayashi I. Nakagawa M, et al. Among authors: machida y. Oncogene. 2019 Oct;38(42):6835-6849. doi: 10.1038/s41388-019-0929-9. Epub 2019 Aug 12. Oncogene. 2019. PMID: 31406254
A Potent Blood-Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model.
Machida Y, Nakagawa M, Matsunaga H, Yamaguchi M, Ogawara Y, Shima Y, Yamagata K, Katsumoto T, Hattori A, Itoh M, Seki T, Nishiya Y, Nakamura K, Suzuki K, Imaoka T, Baba D, Suzuki M, Sampetrean O, Saya H, Ichimura K, Kitabayashi I. Machida Y, et al. Mol Cancer Ther. 2020 Feb;19(2):375-383. doi: 10.1158/1535-7163.MCT-18-1349. Epub 2019 Nov 14. Mol Cancer Ther. 2020. PMID: 31727689
The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.
Takeuchi Y, Kimura N, Murayama T, Machida Y, Iejima D, Nishimura T, Terashima M, Wang Y, Li M, Sakamoto R, Yamamoto M, Itano N, Inoue Y, Ito M, Yoshida N, Inoue JI, Akashi K, Saya H, Fujita K, Kuroda M, Kitabayashi I, Voon D, Suzuki T, Tojo A, Gotoh N. Takeuchi Y, et al. Among authors: machida y. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2103658118. doi: 10.1073/pnas.2103658118. Proc Natl Acad Sci U S A. 2021. PMID: 34663724 Free PMC article.
Novel canine isocitrate dehydrogenase 1 mutation Y208C attenuates dimerization ability.
Kawakami S, Michishita M, Sakaue M, Morimatsu M, Uemura M, Kashiwagi N, Maeda M, Machida Y, Azakami D, Egusa AS, Onozawa E, Ishioka K, Watanabe M, Tanaka Y, Omi T, Ochiai K. Kawakami S, et al. Among authors: machida y. Oncol Lett. 2020 Dec;20(6):351. doi: 10.3892/ol.2020.12214. Epub 2020 Oct 11. Oncol Lett. 2020. PMID: 33123262 Free PMC article.
Primary Lymphangiosarcoma of the Urinary Bladder in a Dog.
Michishita M, Ishizaki Y, Konnai M, Machida Y, Nakahira R, Hatakeyama H, Yoshimura H, Yamamoto M, Soeta S, Ochiai K, Misawa K, Yugeta N, Azakami D. Michishita M, et al. Among authors: machida y. J Comp Pathol. 2020 Aug;179:31-35. doi: 10.1016/j.jcpa.2020.06.014. Epub 2020 Aug 10. J Comp Pathol. 2020. PMID: 32958144
Diffuse Pulmonary Meningotheliomatosis with Sarcomatous Transformation in a Shiba Dog.
Michishita M, Fujiwara-Igarashi A, Suzuki S, Hatakeyama H, Machida Y, Yoshimura H, Yamamoto M, Azakami D, Ochiai K, Ishiwata T, Fujita M. Michishita M, et al. Among authors: machida y. J Comp Pathol. 2019 Aug;171:1-5. doi: 10.1016/j.jcpa.2019.06.005. Epub 2019 Jul 30. J Comp Pathol. 2019. PMID: 31540619 Free PMC article.
Involvement of Nestin in the Progression of Canine Mammary Carcinoma.
Yoshimura H, Moriya M, Yoshida A, Yamamoto M, Machida Y, Ochiai K, Michishita M, Nakagawa T, Matsuda Y, Takahashi K, Kamiya S, Ishiwata T. Yoshimura H, et al. Among authors: machida y. Vet Pathol. 2021 Sep;58(5):994-1003. doi: 10.1177/03009858211018656. Epub 2021 May 31. Vet Pathol. 2021. PMID: 34056976
874 results