Chu X - Search Results

1

Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3.

Gu YZ, Chu X, Houle R, Vlasakova K, Koeplinger KA, Bourgeois I, Palyada K, Anderson KD, Brynczka C, Bhatt B, Chen F, Smith R, Amin R, Glaab WE, Lebron J, Cox K, Sistare FD. Gu YZ, et al. Among authors: chu x. Toxicol Sci. 2019 Nov 1;172(1):155-166. doi: 10.1093/toxsci/kfz186. Toxicol Sci. 2019. PMID: 31406999

2

Raltegravir has a low propensity to cause clinical drug interactions through inhibition of major drug transporters: an in vitro evaluation.

Rizk ML, Houle R, Chan GH, Hafey M, Rhee EG, Chu X. Rizk ML, et al. Among authors: chu x. Antimicrob Agents Chemother. 2014;58(3):1294-301. doi: 10.1128/AAC.02049-13. Epub 2013 Dec 2. Antimicrob Agents Chemother. 2014. PMID: 24295974 Free PMC article.

3

Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin.

Prueksaritanont T, Chu X, Evers R, Klopfer SO, Caro L, Kothare PA, Dempsey C, Rasmussen S, Houle R, Chan G, Cai X, Valesky R, Fraser IP, Stoch SA. Prueksaritanont T, et al. Among authors: chu x. Br J Clin Pharmacol. 2014 Sep;78(3):587-98. doi: 10.1111/bcp.12377. Br J Clin Pharmacol. 2014. PMID: 24617605 Free PMC article. Clinical Trial.

4

Role of transporters in the disposition of a novel β-lactamase inhibitor: relebactam (MK-7655).

Chan G, Houle R, Lin M, Yabut J, Cox K, Wu J, Chu X. Chan G, et al. Among authors: chu x. J Antimicrob Chemother. 2019 Jul 1;74(7):1894-1903. doi: 10.1093/jac/dkz101. J Antimicrob Chemother. 2019. PMID: 30891606

5

In Vitro Assessment of Transporter Mediated Perpetrator DDIs for Several Hepatitis C Virus Direct-Acting Antiviral Drugs and Prediction of DDIs with Statins Using Static Models.

Chu X, Chan GH, Houle R, Lin M, Yabut J, Fandozzi C. Chu X, et al. AAPS J. 2022 Mar 21;24(3):45. doi: 10.1208/s12248-021-00677-8. AAPS J. 2022. PMID: 35314909

6

Selection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition Assays.

Yabut J, Houle R, Wang S, Liaw A, Katwaru R, Collier H, Hittle L, Chu X. Yabut J, et al. Among authors: chu x. Drug Metab Dispos. 2022 Jul;50(7):909-922. doi: 10.1124/dmd.121.000807. Epub 2022 Apr 29. Drug Metab Dispos. 2022. PMID: 35489778

7

Evaluation of the Selectivity of Several Organic Anion Transporting Polypeptide 1B Biomarkers Using Relative Activity Factor Method.

Chan GH, Houle R, Zhang J, Katwaru R, Li Y, Chu X. Chan GH, et al. Among authors: chu x. Drug Metab Dispos. 2023 Sep;51(9):1089-1104. doi: 10.1124/dmd.122.000972. Epub 2023 May 3. Drug Metab Dispos. 2023. PMID: 37137718

8

Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions.

Chu X, Chan GH, Evers R. Chu X, et al. J Pharm Sci. 2017 Sep;106(9):2357-2367. doi: 10.1016/j.xphs.2017.04.007. Epub 2017 Apr 14. J Pharm Sci. 2017. PMID: 28416420 Review.

9

Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity.

Evers R, Chu XY. Evers R, et al. Mol Pharmacol. 2008 Aug;74(2):309-11. doi: 10.1124/mol.108.048991. Epub 2008 May 20. Mol Pharmacol. 2008. PMID: 18492796 Review.

10

Species differences in drug transporters and implications for translating preclinical findings to humans.

Chu X, Bleasby K, Evers R. Chu X, et al. Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):237-52. doi: 10.1517/17425255.2013.741589. Epub 2012 Dec 21. Expert Opin Drug Metab Toxicol. 2013. PMID: 23256482 Review.

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