Gu YZ - Search Results

1

Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3.

Gu YZ, Chu X, Houle R, Vlasakova K, Koeplinger KA, Bourgeois I, Palyada K, Anderson KD, Brynczka C, Bhatt B, Chen F, Smith R, Amin R, Glaab WE, Lebron J, Cox K, Sistare FD. Gu YZ, et al. Toxicol Sci. 2019 Nov 1;172(1):155-166. doi: 10.1093/toxsci/kfz186. Toxicol Sci. 2019. PMID: 31406999

2

Validation of putative genomic biomarkers of nephrotoxicity in rats.

Wang EJ, Snyder RD, Fielden MR, Smith RJ, Gu YZ. Wang EJ, et al. Among authors: gu yz. Toxicology. 2008 Apr 18;246(2-3):91-100. doi: 10.1016/j.tox.2007.12.031. Epub 2008 Jan 16. Toxicology. 2008. PMID: 18289764

3

Towards consensus practices to qualify safety biomarkers for use in early drug development.

Sistare FD, Dieterle F, Troth S, Holder DJ, Gerhold D, Andrews-Cleavenger D, Baer W, Betton G, Bounous D, Carl K, Collins N, Goering P, Goodsaid F, Gu YZ, Guilpin V, Harpur E, Hassan A, Jacobson-Kram D, Kasper P, Laurie D, Lima BS, Maciulaitis R, Mattes W, Maurer G, Obert LA, Ozer J, Papaluca-Amati M, Phillips JA, Pinches M, Schipper MJ, Thompson KL, Vamvakas S, Vidal JM, Vonderscher J, Walker E, Webb C, Yu Y. Sistare FD, et al. Among authors: gu yz. Nat Biotechnol. 2010 May;28(5):446-54. doi: 10.1038/nbt.1634. Epub 2010 May 10. Nat Biotechnol. 2010. PMID: 20458314

4

Toxicoepigenetic alteration of the kidney injury molecule 1 gene in gentamicin-exposed rat kidney.

Chen F, Smith R, Gu YZ, Collins ND, Nioi P. Chen F, et al. Among authors: gu yz. Toxicol Sci. 2010 Oct;117(2):375-80. doi: 10.1093/toxsci/kfq202. Epub 2010 Jul 21. Toxicol Sci. 2010. PMID: 20660082

5

Evaluation of the relative performance of 12 urinary biomarkers for renal safety across 22 rat sensitivity and specificity studies.

Vlasakova K, Erdos Z, Troth SP, McNulty K, Chapeau-Campredon V, Mokrzycki N, Muniappa N, Gu YZ, Holder D, Bailey WJ, Sistare FD, Glaab WE. Vlasakova K, et al. Among authors: gu yz. Toxicol Sci. 2014 Mar;138(1):3-20. doi: 10.1093/toxsci/kft330. Epub 2013 Dec 21. Toxicol Sci. 2014. PMID: 24361871

6

Performance Assessment of New Urinary Translational Safety Biomarkers of Drug-induced Renal Tubular Injury in Tenofovir-treated Cynomolgus Monkeys and Beagle Dogs.

Gu YZ, Vlasakova K, Troth SP, Peiffer RL, Tournade H, Pasello Dos Santos FR, Glaab WE, Sistare FD. Gu YZ, et al. Toxicol Pathol. 2018 Jul;46(5):553-563. doi: 10.1177/0192623318775023. Epub 2018 May 28. Toxicol Pathol. 2018. PMID: 29807506

7

Urine kidney safety biomarkers improve understanding of indirect intra-renal injury potential in dogs with a drug-induced prerenal azotemia.

Gu YZ, Vlasakova K, Darbes J, Wang E, Ferraro J, Glaab WE, Sistare FD. Gu YZ, et al. Toxicology. 2020 Jun;439:152462. doi: 10.1016/j.tox.2020.152462. Epub 2020 Apr 27. Toxicology. 2020. PMID: 32348786

8

The Utility of Novel Urinary Biomarkers in Mice for Drug Development Studies.

Adedeji AO, Gu YZ, Pourmohamad T, Kanerva J, Chen Y, Atabakhsh E, Tackett MR, Chen F, Bhatt B, Gury T, Dorchies O, Sonee M, Morgan M, Burkey J, Gautier JC, McDuffie JE. Adedeji AO, et al. Among authors: gu yz. Int J Toxicol. 2021 Jan-Feb;40(1):15-25. doi: 10.1177/1091581820970498. Epub 2020 Nov 9. Int J Toxicol. 2021. PMID: 33161787

9

Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling.

Gu YZ, Handt L, Vlasakova K, Bakthavatchalu V, Smith R, Fernandez GE, Born SL, Glaab WE, Sistare FD. Gu YZ, et al. Toxicol Pathol. 2022 Jan;50(1):35-46. doi: 10.1177/01926233211049171. Epub 2021 Oct 17. Toxicol Pathol. 2022. PMID: 34657537

10

Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats.

Gu YZ, Vlasakova K, Miller G, Gatto NT, Ciaccio PJ, Kuruvilla S, Besteman EG, Smith R, Reynolds SJ, Amin RP, Glaab WE, Wollenberg G, Lebron J, Sistare FD. Gu YZ, et al. Toxicol Pathol. 2023 Jan;51(1-2):15-26. doi: 10.1177/01926233231162809. Epub 2023 Apr 20. Toxicol Pathol. 2023. PMID: 37078689

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