Houle R - Search Results

1

Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3.

Gu YZ, Chu X, Houle R, Vlasakova K, Koeplinger KA, Bourgeois I, Palyada K, Anderson KD, Brynczka C, Bhatt B, Chen F, Smith R, Amin R, Glaab WE, Lebron J, Cox K, Sistare FD. Gu YZ, et al. Among authors: houle r. Toxicol Sci. 2019 Nov 1;172(1):155-166. doi: 10.1093/toxsci/kfz186. Toxicol Sci. 2019. PMID: 31406999

2

Role of transporters in the disposition of a novel β-lactamase inhibitor: relebactam (MK-7655).

Chan G, Houle R, Lin M, Yabut J, Cox K, Wu J, Chu X. Chan G, et al. Among authors: houle r. J Antimicrob Chemother. 2019 Jul 1;74(7):1894-1903. doi: 10.1093/jac/dkz101. J Antimicrob Chemother. 2019. PMID: 30891606

3

A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery.

Hafey MJ, Houle R, Tanis KQ, Knemeyer I, Shang J, Chen Q, Baudy A, Monroe J, Sistare FD, Evers R. Hafey MJ, et al. Among authors: houle r. Drug Metab Dispos. 2020 Nov;48(11):1147-1160. doi: 10.1124/dmd.120.000086. Epub 2020 Sep 17. Drug Metab Dispos. 2020. PMID: 32943412

4

In Vitro Assessment of Transporter Mediated Perpetrator DDIs for Several Hepatitis C Virus Direct-Acting Antiviral Drugs and Prediction of DDIs with Statins Using Static Models.

Chu X, Chan GH, Houle R, Lin M, Yabut J, Fandozzi C. Chu X, et al. Among authors: houle r. AAPS J. 2022 Mar 21;24(3):45. doi: 10.1208/s12248-021-00677-8. AAPS J. 2022. PMID: 35314909

5

Raltegravir has a low propensity to cause clinical drug interactions through inhibition of major drug transporters: an in vitro evaluation.

Rizk ML, Houle R, Chan GH, Hafey M, Rhee EG, Chu X. Rizk ML, et al. Among authors: houle r. Antimicrob Agents Chemother. 2014;58(3):1294-301. doi: 10.1128/AAC.02049-13. Epub 2013 Dec 2. Antimicrob Agents Chemother. 2014. PMID: 24295974 Free PMC article.

6

Selection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition Assays.

Yabut J, Houle R, Wang S, Liaw A, Katwaru R, Collier H, Hittle L, Chu X. Yabut J, et al. Among authors: houle r. Drug Metab Dispos. 2022 Jul;50(7):909-922. doi: 10.1124/dmd.121.000807. Epub 2022 Apr 29. Drug Metab Dispos. 2022. PMID: 35489778

7

Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin.

Prueksaritanont T, Chu X, Evers R, Klopfer SO, Caro L, Kothare PA, Dempsey C, Rasmussen S, Houle R, Chan G, Cai X, Valesky R, Fraser IP, Stoch SA. Prueksaritanont T, et al. Among authors: houle r. Br J Clin Pharmacol. 2014 Sep;78(3):587-98. doi: 10.1111/bcp.12377. Br J Clin Pharmacol. 2014. PMID: 24617605 Free PMC article. Clinical Trial.

8

Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters.

Bleasby K, Houle R, Hafey M, Lin M, Guo J, Lu B, Sanchez RI, Fillgrove KL. Bleasby K, et al. Among authors: houle r. Viruses. 2021 Aug 7;13(8):1566. doi: 10.3390/v13081566. Viruses. 2021. PMID: 34452431 Free PMC article.

9

In Vitro Evaluation of the Drug Interaction Potential of Doravirine.

Bleasby K, Fillgrove KL, Houle R, Lu B, Palamanda J, Newton DJ, Lin M, Chan GH, Sanchez RI. Bleasby K, et al. Among authors: houle r. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02492-18. doi: 10.1128/AAC.02492-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30745395 Free PMC article.

10

Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.

Chen HY, Plummer CW, Xiao D, Chobanian HR, DeMong D, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Di Salvo J, Thomas-Fowlkes B, Souza S, Tatosian DA, Chen Q, Hafey MJ, Houle R, Nolting AF, Orr R, Ehrhart J, Weinglass AB, Tschirret-Guth R, Howard AD, Colletti SL. Chen HY, et al. Among authors: houle r. ACS Med Chem Lett. 2018 Jun 14;9(7):685-690. doi: 10.1021/acsmedchemlett.8b00149. eCollection 2018 Jul 12. ACS Med Chem Lett. 2018. PMID: 30034601 Free PMC article.

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