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Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities.
Yenerall P, Sung T, Palyada K, Qian J, Arat S, Kumpf SW, Wang SW, Biddle K, Esparza C, Chang S, Scott W, Collette W, Winrow TS, Affolter T, Shirai N, Thibault S, Wang J, Liu L, Bauchmann M, Frey J, Steyn S, Sacaan A, Vitsky A, Ahn Y, Paul T, Lum L, Oyer J, Yang A, Hu W. Yenerall P, et al. Among authors: palyada k. Toxicol Sci. 2023 Jun 28;194(1):53-69. doi: 10.1093/toxsci/kfad049. Toxicol Sci. 2023. PMID: 37228089 Free PMC article.
Session 5: Protein Degraders.
Palyada K, Hukkanen R, Leuenroth-Quinn S, Vitsky A, Peterson R, Stamp K, Hoover C, Volak L. Palyada K, et al. Toxicol Pathol. 2024 Dec 11:1926233241300452. doi: 10.1177/01926233241300452. Online ahead of print. Toxicol Pathol. 2024. PMID: 39660628
Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice.
Marangoni D, Bush RA, Zeng Y, Wei LL, Ziccardi L, Vijayasarathy C, Bartoe JT, Palyada K, Santos M, Hiriyanna S, Wu Z, Colosi P, Sieving PA. Marangoni D, et al. Among authors: palyada k. Mol Ther Methods Clin Dev. 2016 Mar 16;5:16011. doi: 10.1038/mtm.2016.11. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 27626041 Free PMC article.
Diffuse cutaneous mastocytosis in a newborn calf.
Palyada KS, Scott DW, Schlafer DH, Czajkowski M. Palyada KS, et al. Vet Dermatol. 2008 Jun;19(3):184-6. doi: 10.1111/j.1365-3164.2008.00666.x. Vet Dermatol. 2008. PMID: 18477335
14 results