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Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study.
van Os J, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran EŞ, Kaymak SU, Mihaljevic MM, Petrovic SA, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz PA, García-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric NP, Atbaşoğlu C, Ucok A, Alptekin K, Saka MC; Genetic Risk and Outcome Investigators (GROUP); Arango C, O'Donovan M, Rutten BPF, Guloksuz S. van Os J, et al. Among authors: petrovic sa. Psychol Med. 2020 Aug;50(11):1884-1897. doi: 10.1017/S003329171900196X. Epub 2019 Aug 15. Psychol Med. 2020. PMID: 31414981
Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study.
Guloksuz S, Pries LK, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak SU, Mihaljevic MM, Petrovic SA, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz PA, García-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric NP, Atbaşog Lu C, Ucok A, Alptekin K, Saka MC; Genetic Risk and Outcome of Psychosis (GROUP) investigators; Arango C, O'Donovan M, Rutten BPF, van Os J. Guloksuz S, et al. Among authors: petrovic sa. World Psychiatry. 2019 Jun;18(2):173-182. doi: 10.1002/wps.20629. World Psychiatry. 2019. PMID: 31059627 Free PMC article.
Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study.
Pries LK, Lage-Castellanos A, Delespaul P, Kenis G, Luykx JJ, Lin BD, Richards AL, Akdede B, Binbay T, Altinyazar V, Yalinçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran EŞ, Kaymak SU, Mihaljevic MM, Petrovic SA, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz PA, García-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric NP, Atbaşoğlu C, Ucok A, Alptekin K, Saka MC; Genetic Risk and Outcome of Psychosis (GROUP) investigators; Arango C, O'Donovan M, Rutten BPF, van Os J, Guloksuz S. Pries LK, et al. Among authors: petrovic sa. Schizophr Bull. 2019 Sep 11;45(5):960-965. doi: 10.1093/schbul/sbz054. Schizophr Bull. 2019. PMID: 31508804 Free PMC article.
Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway.
van Os J, Pries LK, Ten Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin BD, Luykx JJ, Richards AL, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran EŞ, Kaymak SU, Mihaljevic MM, Petrovic SA, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz PA, García-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric NP, Atbaşoğlu C, Ucok A, Alptekin K, Saka MC, Arango C, O'Donovan M, Rutten BPF, Guloksuz S. van Os J, et al. Among authors: petrovic sa. Psychol Med. 2022 Jul;52(10):1910-1922. doi: 10.1017/S0033291720003748. Epub 2020 Oct 19. Psychol Med. 2022. PMID: 33070791
Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings.
Velthorst E, Mollon J, Murray RM, de Haan L, Germeys IM, Glahn DC, Arango C, van der Ven E, Di Forti M, Bernardo M, Guloksuz S, Delespaul P, Mezquida G, Amoretti S, Bobes J, Saiz PA, García-Portilla MP, Santos JL, Jiménez-López E, Sanjuan J, Aguilar EJ, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Atbaşoğlu C, Saka MC, Üçok A, Alptekin K, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, Beyaz BC, Soygür H, Cankurtaran EŞ, Kaymak SU, Maric NP, Mihaljevic MM, Petrovic SA, Mirjanic T, Del-Ben CM, Ferraro L, Gayer-Anderson C, Jones PB, Jongsma HE, Kirkbride JB, La Cascia C, Lasalvia A, Tosato S, Llorca PM, Menezes PR, Morgan C, Quattrone D, Menchetti M, Selten JP, Szöke A, Tarricone I, Tortelli A, McGuire P, Valmaggia L, Kempton MJ, van der Gaag M, Riecher-Rössler A, Bressan RA, Barrantes-Vidal N, Nelson B, McGorry P, Pantelis C, Krebs MO, Ruhrmann S, Sachs G, Rutten BPF, van Os J, Alizadeh BZ, van Amelsvoort T, Bartels-Velthuis AA, Bruggeman R, van Beveren NJ, Luykx JJ, Cahn W, Simons CJP, Kahn RS, Schirmbeck F, van Winkel R; EU-GEI High Risk Study; Reichenberg A. Velthorst E, et al. Among authors: petrovic sa. Mol Psychiatry. 2021 Aug;26(8):4529-4543. doi: 10.1038/s41380-020-00969-z. Epub 2021 Jan 7. Mol Psychiatry. 2021. PMID: 33414498
The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls.
Mihaljevic M, Franic D, Soldatovic I, Lukic I, Petrovic SA, Mirjanic T, Stankovic B, Zukic B, Zeljic K, Gasic V, Novakovic I, Pavlovic S, Adzic M, Maric NP. Mihaljevic M, et al. Among authors: petrovic sa. Psychoneuroendocrinology. 2021 Jun;128:105205. doi: 10.1016/j.psyneuen.2021.105205. Epub 2021 Mar 23. Psychoneuroendocrinology. 2021. PMID: 33933892